NDLI: Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Verheus, Martijn Van Gils, Carla H. Kreijkamp-Kaspers, Sanne Kok, Linda Peeters, Petra H. M. Grobbee, Diederick E. Van Der Schouw, Yvonne T.
Spatial Coverage	Netherlands
Description	Country affiliation: Netherlands Author Affiliation: Verheus M ( Julius Center for Health Sciences and Primary Care, University Medical Center, Room Str 6.131, P. O. Box 85500, Utrecht 3508 GA, Utrecht, the Netherlands.)
Abstract	BACKGROUND: The relatively high dietary intake of soy in Asian countries has been hypothesized to, at least partly, explain the lower breast cancer incidence patterns in these countries compared with the Western world. The aim of the present study was to determine the effect of daily soy supplementation on mammographic density, one of the strongest known risk factors for breast cancer. METHODS: A double-blind, randomized, controlled trial was conducted to compare the effects of soy protein intake containing 99 mg isoflavones daily with intake of milk protein (placebo) for the duration of 1 year. Two hundred and two Dutch postmenopausal women ages 60 to 75 years were randomized. Mammographic density was assessed using a quantitative computer-assisted method on digitized mammograms. Equol producer status was assessed in plasma provided at the final visit (soy group) or after a 3-day challenge with soy after the trial was finished (placebo group). RESULTS: A total of 175 women completed the baseline visits and at least one follow-up visit and were included in the intention-to-treat analyses. For 126 women, both pre- and post-trial mammograms were available. Mammographic density decreased in both study arms, but the decrease did not differ significantly between intervention and placebo groups. Equol producer status did not modify the results. CONCLUSION: The results of this trial do not support the hypothesis that a diet high in soy protein among postmenopausal women decreases mammographic density.
File Format	HTM / HTML
ISSN	10559965
e-ISSN	15387755
Journal	Cancer Epidemiology Biomarkers & Prevention
Issue Number	10
Volume Number	17
Language	English
Publisher	American Association for Cancer Research
Publisher Date	2008-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cancer epidemiology Breast Neoplasms Isoflavones Administration & Dosage Soybean Proteins Epidemiology Double-blind Method Pharmacology Mammography Netherlands Postmenopause Regression Analysis Risk Factors Comparative Study Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Epidemiology Oncology

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