NDLI: Effects of soy isoflavones on mammographic density and breast parenchyma in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial.

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Effects of soy isoflavones on mammographic density and breast parenchyma in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Delmanto, Armando Nahas-Neto, Jorge Traiman, Paulo Uemura, Gilberto Pessoa, Eduardo Carvalho Nahas, Eliana Aguiar Petri
Description	Country affiliation: Brazil Author Affiliation: Delmanto A ( From the Department of Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University (UNESP), São Paulo, Brazil.)
Abstract	OBJECTIVE: This study aims to evaluate the effects of soy isoflavones on breast tissue in postmenopausal women. METHODS: In this randomized, double-blind, placebo-controlled study, 80 women (aged ≥ 45 y and with amenorrhea >12 mo) with vasomotor symptoms were randomized to receive either 250 mg of standardized soy extract corresponding to isoflavone 100 mg/day (n = 40) or placebo (n = 40) for 10 months. Breasts were evaluated through mammographic density and breast parenchyma using ultrasound (US) at baseline and 10-month follow-up. Independent t test, analysis of variance, Mann-Whitney U test, and χ2 trend test were used in statistical analysis. RESULTS: Baseline clinical characteristics showed no significant differences between the isoflavone group and the placebo group, with mean (SD) age of 55.1 (6.0) and 56.2 (7.7) years, mean (SD) menopause duration of 6.6 (4.8) and 7.1 (4.2) years, and mean (SD) body mass index of 29.7 (5.0) and 28.5 (4.9) kg/m2, respectively (P > 0.05). The study was completed by 32 women on isoflavone and 34 women on placebo. The groups did not differ in mammographic density or breast parenchyma by US (P > 0.05). Within each group, the baseline and final moments did not differ in mammography or US parameters significantly (P > 0.05). CONCLUSIONS: The use of soy isoflavone extract for 10 months does not affect breast density, as assessed by mammography and US, in postmenopausal women.
File Format	HTM / HTML
ISSN	10723714
Issue Number	10
Volume Number	20
e-ISSN	15300374
Journal	Menopause: The Journal of The North American Menopause Society
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2013-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Gynecology Breast Neoplasms Breast Drug Effects Isoflavones Administration & Dosage Adverse Effects Mammary Glands, Human Abnormalities Postmenopause Soybeans Chemistry Body Mass Index Double-blind Method Female Genistein Blood Humans Mammography Middle Aged Placebos Plant Extracts Ultrasonography, Mammary Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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