NDLI: Association between TP53 Arg72Pro polymorphism and thyroid carcinoma risk.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Fang Wang, Peng Wang, Bin Fu, Zheng-Ju Yuan, Ying Yan, Sheng-Li Zhao, Wen-Juan Wang, Yan-Gang
Description	Country affiliation: China Author Affiliation: Wang F ( Department of Endocrinology, The Affiliated Hospital of Medical College, Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.)
Abstract	TP53 Arg72Pro polymorphism has been proposed to have some effects on host's susceptibility to cancer. Several studies were published to assess the association between TP53 Arg72Pro polymorphism and thyroid carcinoma, but they reported controversial results. We performed a systemic review and meta-analysis to assess the association between TP53 Arg72Pro polymorphism and thyroid carcinoma. Odds ratio (OR) with 95% confidence interval (95% CI) was used to assess the association. Fourteen individual studies with 3,483 subjects were finally included into the meta-analysis. Overall, there was an obvious association between TP53 Arg72Pro polymorphism and thyroid carcinoma under the recessive model (ProPro vs. ArgArg/ArgPro, OR = 2.02, 95% CI 1.13 to 3.62, P = 0.02). Subgroup analysis by race showed that TP53 Arg72Pro polymorphism was associated with thyroid carcinoma in Caucasians (ProPro vs. ArgArg/ArgPro, OR = 2.31, 95% CI 1.08 to 4.93, P = 0.03). Subgroup analysis by histological type showed that TP53 Arg72Pro polymorphism was not associated with a risk of different types of thyroid carcinoma. In summary, the meta-analysis suggests that TP53 Arg72Pro polymorphism is associated with thyroid carcinoma risk in Caucasians. Besides, more studies with large sample size are needed to further assess the associations above.
File Format	HTM / HTML
ISSN	10104283
Issue Number	3
Volume Number	35
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2014-03-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Genetic Predisposition To Disease Genetics Polymorphism, Single Nucleotide Thyroid Neoplasms Tumor Suppressor Protein P53 Case-control Studies European Continental Ancestry Group Humans Odds Ratio Journal Article Meta-analysis
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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