NDLI: Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yan, Yulan Liang, Hongjie Xie, Li He, Yu Li, Meng Li, Ruolin Li, Shan Qin, Xue
Description	Author Affiliation: Yan Y ( Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, People's Republic of China, xueying201120521@163.com.)
Abstract	UNLABELLED: In the light of the relationship between the MDR1 G2677T polymorphism and the risk of leukemia remains inclusive or controversial. For better understanding of the effect of MDR1 G2677T polymorphism on leukemia risk, we performed a meta-analysis. Eligible studies were identified through a search of electronic databases such as PubMed, Excerpta Medica Database (Embase), Cochrane Library, and Chinese Biomedical Literature Database (CBM). The association between the MDR1 G2677T polymorphism and leukemia risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CI). A total of seven publications including eight studies with 1,229 cases and 1,097 controls were included in the meta-analysis. There was no association between MDR1 G2677T polymorphism and leukemia risk in all of five models in overall populations (T vs. G: OR = 1.00, 95% CI = 0.88-1.12, P = 0.914; TT vs. GG: OR = 0.97, 95% CI = 0.75-1.26, P = 0.812; TG vs. GG: OR = 1.00, 95% CI = 0.92-1.08, P = 0.939; TT vs. TG/GG: OR = 0.98, 95% CI = 0.67-1.43, P = 0.906; TT/TG vs. GG: OR = 1.00, 95% CI = 0.95-1.06, P = 0.994). However, the significant association was found in others (Table 2) under the homozygote model (TT vs. GG: OR = 0.68, 95% CI = 0.48-0.94, P = 0.020) and recessive model (TT vs. TG/GG: OR = 0.63, 95% CI = 0.43-0.92, P = 0.016). In the subgroup analysis, according to the type of leukemia, significant association was found between MDR1 G2677T polymorphism and myeloid leukemia but not lymphoblastic leukemia (TT vs. GG: OR = 0.66, 95% CI = 0.46-0.95, P = 0.026; TT vs. TG/GG: OR = 0.56, 95% CI = 0.38-0.84, P = 0.005). The results suggested that there was no association between MDR1 G2677T polymorphism and leukemia risk in overall populations, but significant association was found in others populations (Asians and Africans), and myeloid leukemia indicated that G2677T polymorphism might be a protective factor in the susceptibility of myeloid leukemia and in Asians and Africans.
File Format	HTM / HTML
ISSN	10104283
e-ISSN	14230380
DOI	10.1007/s13277-013-1291-0
Journal	Tumor Biology
Issue Number	3
Volume Number	35
Language	English
Publisher	Springer
Publisher Date	2014-03-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Medicine__semicolon__oncology Genetic Predisposition To Disease Genetics Leukemia P-glycoprotein Polymorphism, Single Nucleotide Genotype Odds Ratio Risk Factors Meta-analysis
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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