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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Glinka, Elena M. |
| Description | Author Affiliation: Glinka EM ( , Voljskii bulvar 95, 3/244, Moscow, 109125, Russia, em_glinka@mail.ru.) |
| Abstract | Cancer gene therapy vectors are promising tools for killing cancer cells with the purpose of eradicating malignant tumours entirely. Different delivery methods of vectors into the cancer cells, including both non-viral and viral, as well as promoters for the targeted expression of genes encoding anticancer proteins were developed for effective and selective killing of cancer cells without harming healthy cells. Many vectors have been created to kill cancer cells, and some vectors suppress malignant tumours with high efficiency. This review is focused on vectors bearing genes for nucleases such as deoxyribonucleases (caspase-activated DNase, deoxyribonuclease I-like 3, endonuclease G) and ribonucleases (human polynucleotide phosphorylase, ribonuclease L, -sarcin, barnase), as well as vectors harbouring gene encoding ribonuclease inhibitor. The data concerning the functionality and the efficacy of such vectors are presented. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 5 |
| Volume Number | 36 |
| e-ISSN | 14230380 |
| Journal | Tumor Biology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Medicine__semicolon__oncology Deoxyribonucleases Genetics Neoplasms Therapy Placental Hormones Animals Apoptosis Gene Transfer Techniques Genetic Therapy Genetic Vectors Humans Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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