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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Akrami, Hassan Aminzadeh, Saman Fallahi, Hossein |
| Description | Author Affiliation: Akrami H ( Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran, hassan_akrami@yahoo.com.) |
| Abstract | Numerous epidemiological studies have suggested effectiveness of long-term and regular use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and aspirin, in preventing and treatment of certain cancers including prostate, colon, breast, lung, and gastric cancers. We have studied the potential anti-turmeric effect of ibuprofen in adenocarcinoma gastric cell line (AGS). The effects of ibuprofen were investigated on cell proliferation, apoptosis, angiogenesis, and expression of stemness marker genes using real-time RT-PCR, DNA laddering, and tube formation assays via ECM gel and human umbilical vein endothelial cells (HUVECs). Annexin-V-FLUOS and propidium iodide (PI) were used to stain the apoptotic cells. Our findings indicate that ibuprofen at the concentrations of 100, 200, 300, 400, and 500 µM is able to reduce the cancerous characteristics of the AGS cells by inducing apoptosis, inhibition of cell proliferation, and angiogenesis. Real-time RT-PCR showed that ibuprofen altered the expression of several genes including Akt, P53, PCNA, Bax, and Bcl2 in the AGS cells. In addition, reduction in CD44 and OCT3/4 transcript levels revealed that ibuprofen reduces the stemness of the AGS cells and therefore it could be used as a potential anti-tumor drug. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 5 |
| Volume Number | 36 |
| e-ISSN | 14230380 |
| Journal | Tumor Biology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Medicine__semicolon__oncology Angiogenesis Inhibitors Pharmacology Cell Survival Drug Effects Ibuprofen Stomach Neoplasms Drug Therapy Apoptosis Cell Line, Tumor Drug Screening Assays, Antitumor Humans Inhibitory Concentration 50 Transcriptome Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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