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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | He, Jian Ying Xi, Wei Hong Zhu, Liang Bo Long, Xin Hua Chen, Xuan Yin Liu, Jia Min Luo, Qin Feng Zhu, Xiao Ping Liu, Zhi Li |
| Description | Author Affiliation: He JY ( The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People's Republic of China.) |
| Abstract | The aim of this study is to investigate the effects of inhibiting Aurora-B on osteosarcoma (OS) cell malignant phenotype, phosphorylation of valosin-containing protein (VCP), and the activity of NF-κB signaling in vitro. The expressions of Aurora-B and p-VCP proteins were detected by immunohistochemistry in 24 OS tissues, and the relationship between Aurora-B and p-VCP was investigated. The results showed that there was a positive correlation between Aurora-B and p-VCP proteins. The expression of Aurora-B in human OS cell lines U2-OS and HOS cells was inhibited by specific short hairpin RNA (shRNA) lentivirus (AURKB-shRNA lentivirus, Lv-shAURKB) which targeted Aurora-B. The results showed that the phosphorylation of VCP, the activity of NF-κB signaling pathway and the malignant phenotype of OS cells were all suppressed by knockdown of Aurora-B. It indicated that the inhibition of Aurora-B alters OS cells malignant phenotype by downregulating phosphorylation of VCP and activating of the NF-κB signaling pathway in vitro. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 5 |
| Volume Number | 36 |
| e-ISSN | 14230380 |
| Journal | Tumor Biology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Medicine__semicolon__oncology Adenosine Triphosphatases Biosynthesis Aurora Kinase B Genetics Bone Neoplasms Cell Cycle Proteins Nf-kappa B Osteosarcoma Apoptosis Pathology Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Phosphorylation Signal Transduction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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