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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Marín-Gómez, L. M. Gómez-Bravo, M. A. Barrera-Pulido, L. Bernal-Bellido, C. Alamo-Martínez, J. M. Suárez-Artacho, G. Díez-Canedo, J. S. Sousa-Martín, J. M. |
| Description | Country affiliation: Spain Author Affiliation: Marín-Gómez LM ( Liver Transplant Unit, Virgen del Rocío Hospital, Seville, Spain. marinlm@hotmail.com) |
| Abstract | AIMS: Domino liver transplantation (DLT) is a strategy to increase the donor pool. Explanted liver from patients with familial amyloidotic polyneuropathy (FAP) are often used as domino grafts, because the liver is normal apart from the production of the mutated transthyretin variant. We present the outcomes for both donors and recipients of DLT. MATERIALS AND METHODS: Retrospective analysis of initial DLT for 16 consecutive adult patients performed between July 2004 and July 2009. All cases of FAP donor to grafts were removed preserving the cava vein with reconstruction of the hepatic veins, except the first and seventh cases, where in we removed the retrohepatic vena cava with the liver without venovenous bypass. The postoperative follow-up period for surviving DLT recipients at the end of September 2009 was 2-62 months (mean, 26). RESULTS: Two patients out of 8 FAP donors died due to pulmonary thromboembolism on the 31st postransplant day, or sepsis at 35 days namely, an overall survival of 75%. One patient out of 8 recipients died namely, an early portal thrombosis on the 22nd postransplant day) with a crude survival of 87.5% in the recipient group (P = no significant [NS]). Four grafts from 8 FAP donors were lost-2 deaths and 2 retransplants due to thrombotic events on the first and second postransplant day-with a crude survival of 50%. Two of 8 recipients lost their grafts: 1 death and 1 retransplantation for an acute Budd-Chiari syndrome on the first postransplant day with a crude survival of 75% in the recipient group (P = not significant [NS]). CONCLUSION: We believe that the FAP liver graft is an excellent option for selected patients. Special care must be taken with thrombotic events. |
| File Format | HTM / HTML |
| ISSN | 00411345 |
| Issue Number | 2 |
| Volume Number | 42 |
| e-ISSN | 18732623 |
| Journal | Transplantation Proceedings |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation__semicolon__medicine Liver Transplantation Methods Physiology Adult Amyloid Neuropathies, Familial Surgery Female Graft Survival Hepatectomy Humans Informed Consent Liver Failure Mortality Male Middle Aged Postoperative Complications Epidemiology Retrospective Studies Survivors Tissue Donors Waiting Lists Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Surgery |
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