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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pereira, S. Pedroso, S. Martins, L. Santos, P. Almeida, M. Freitas, C. Dias, L. Dores, J. Almeida, R. Castro Henriques, A. Teixeira, M. |
| Description | Country affiliation: Portugal Author Affiliation: Pereira S ( Nephrology Department, Centro Hospitalar de Vila Nova de Gaia, Oporto, Portugal. sujpereira@gmail.com) |
| Abstract | Bone disease and an high risk of fractures are major problems in transplantation. Among diabetic patients undergoing simultaneous kidney-pancreas (SKP) transplantation, there are few studies assessing long-term effects on bone mass. The aim of this study was to evaluate bone mineral density (BMD) over 4 years follow-up after SKP transplantation. Fifty-seven patients had 22.8 +/- 5.3 years of prior diabetes, 65% were female, and the overall mean age was 24.3 +/- 5.93 years. At the time of transplantation, the lumbar spine and femoral neck T-scores were -1.75 +/- 1.05 and -1.95 +/- 0.73, respectively; 28% of subjects had evidence of osteoporosis. One year after transplantation, 77.6% of patients displayed improved lumbar T-scores to -1.33 +/- 0.94 (P = .044) with stable femoral neck T-scores. Bone densitometry enhanced gradually through the 4 years follow-up: lumbar T-score to -1.04 +/- 0.67 (P = .004) and femoral neck T-score to -1.69 +/- 0.49 (P = .12). At year 4, no osteoporosis cases were detected but 86.7% of patients did not receive steroids in the immunosuppressive regimen. The graft function remained stable (serum creatinine, 1.2 mg/dL; fasting glucose, 87.7 mg/dL). During the follow-up, BMD improved more significantly at cortical sites. Our study reports a reduced prevalence of fractures (8.7%) compared with the literature, which could be related to a steroid-sparing protocol and/or aggressively treatment of osteoporosis. |
| File Format | HTM / HTML |
| ISSN | 00411345 |
| Issue Number | 2 |
| Volume Number | 42 |
| e-ISSN | 18732623 |
| Journal | Transplantation Proceedings |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation__semicolon__medicine Bone Density Physiology Kidney Transplantation Pancreas Transplantation Adult Blood Glucose Analysis Cohort Studies Creatinine Blood Female Femur Neck Pathology Follow-up Studies Fractures, Bone Epidemiology Etiology Hemoglobin A, Glycosylated Humans Immunosuppressive Agents Therapeutic Use Adverse Effects Immunology Lumbar Vertebrae Male Osteoporosis Patient Selection Retrospective Studies Spine Young Adult Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Surgery |
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