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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Duca, W. J. da Silva, R. F. Arroyo, P. C. Sgnolf, A. Cabral, C. M. Ayres, D. C. Felício, H. C. C. da Silva, R. D. C. M. A. |
| Description | Country affiliation: Brazil Author Affiliation: Duca WJ ( Medical School in São José do Rio Preto, Hospital de Base, Liver and Intestine Transplantation Unit, São José, Brazil. wjduca@duca.com.br) |
| Abstract | INTRODUCTION: Orthotopic liver transplantation (OLT) is today the gold standard treatment of the end-stage liver disease. Different solutions are used for graft preservation. Our objective was to compare the results of cadaveric donor OLT, preserved with the University of Wisconsin (UW) or Celsior solutions in the portal vein and Euro-Collins in the aorta. METHODS: We evaluated retrospectively 72 OLT recipients, including 36 with UW solution (group UW) and 36 with Celsior (group CS). Donors were perfused in situ with 1000 mL UW or Celsior in the portal vein of and 3000 mL of Euro-Collins in the aortia and on the back table managed with 500 mL UW or Celsior in the portal vein, 250 mL in the hepatic artery, and 250 mL in the biliary duct. We evaluated the following variables: donor characteristics, recipient features, intraoperative details, reperfusion injury, and steatosis via a biopsy after reperfusion. We noted grafts with primary nonfunction (PNF), initial poor function (IPF), rejection episodes, biliary duct complications, hepatic artery complications, re-OLT, and recipient death in the first year after OLT. RESULTS: The average age was 33.6 years in the UW group versus 41 years in the CS group (P = .048). There was a longer duration of surgery in the UW group (P = .001). The other recipient characteristics, ischemia-reperfusion injury, steatosis, PNF, IPF, rejection, re-OLT, and recipient survival were not different. Stenosis of the biliary duct occured in 3 (8.3%) cases in the UW group and 8 (22.2%) in the CS (P = .19) with hepatic artery thrombosis in 4 (11.1%) CS versus none in the UW group (P = .11). CONCLUSION: Cadaveric donor OLT showed similar results with organs preserved with UW or Celsior in the portal vein and Euro-Collins in the aorta. |
| File Format | HTM / HTML |
| ISSN | 00411345 |
| Issue Number | 2 |
| Volume Number | 42 |
| Journal | Transplantation Proceedings |
| e-ISSN | 18732623 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation__semicolon__medicine Aorta, Abdominal Physiology Hypertonic Solutions Therapeutic Use Liver Failure Surgery Liver Transplantation Methods Organ Preservation Solutions Portal Vein Adenosine Adolescent Adult Aged Allopurinol Drug Effects Cadaver Child Child, Preschool Disaccharides Electrolytes Female Glutamates Glutathione Histidine Humans Immunosuppressive Agents Insulin Immunology Male Mannitol Middle Aged Organ Preservation Postoperative Complications Epidemiology Prospective Studies Raffinose Reperfusion Injury Retrospective Studies Tissue Donors Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Surgery |
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