NDLI: Effects of a cGMP-specific phosphodiesterase inhibitor on expression of endothelial nitric oxide synthase and vascular endothelial growth factor in rats with cyclosporine-induced nephrotoxicity.

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Challenging issues of overseas transplantation in mainland China: Taiwan organ transplant health professionals' perspective.

Caring for overseas liver transplant recipients: Taiwan primary family caregivers' experiences in mainland China.

National survey carried out by the Mexican Society of Transplantation in 2009 regarding deceased-donor kidney allocation.

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Is estimated donor glomerular filtration rate before death a better predictor of decreased-donor kidney function?

Computed tomographic angiography and perfusion in the diagnosis of brain death.

Comparable outcomes in donation after cardiac death and donation after brainstem death: a matched analysis of renal transplants.

Predicting donor asystole following withdrawal of treatment in donation after cardiac death.

Impact of cold ischemia on renal transplant outcomes following donation after cardiac death.

Impact of age matching of donors to recipients on renal transplant outcomes following donation after cardiac death.

Kidney injury molecule-1 correlates with kidney function in renal allograft recipients.

Sequential transplant of paired kidneys following donation after cardiac death: impact of longer cold ischemia time on the second kidney on graft and patient outcome.

Outcomes following renal transplantation after multiorgan retrieval versus kidney-only retrieval in donation after cardiac death donors.

Renal transplantation following donation after cardiac death: impact of duration from withdrawal to asystole.

Pulsatile perfusion of kidney allografts with Celsior solution.

Perfusion using oxygenated buffer containing prostaglandin E1 before cold preservation prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors.

Induction of different types of cell death after normothermic liver ischemia-reperfusion.

The effect of HTK solution modification by addition of prolactin on biochemical indices reflecting ischaemic damage to porcine kidney.

Effect of FTY720 treatment on postischemic pancreatic microhemodynamics.

Acceptable residual renal function after retroperitoneoscopic kidney donation in elderly donors.

One hundred six live kidney donors in a single German transplantation center: renal, physical, and psychological follow-up.

Effect of renal transplantation on visual evoked potential abnormalities of chronic renal failure.

Desensitization protocol in highly HLA-sensitized and ABO-incompatible high titer kidney transplantation.

Impact of pretransplant intravenous immunoglobulin administration on anti-AB0 antibody levels in AB0-incompatible living donor kidney transplantation.

Functional status of hemodialysis arteriovenous fistula in kidney transplant recipients as a predictor of allograft function and survival.

New registry and tracking system for renal transplantation in Japan.

Different etiologies of graft loss and death in Asian kidney transplant recipients: a report from Thai Transplant Registry.

Risk factors and outcome of delayed graft function after cadaveric kidney transplantation: a report from the Thai Transplant Registry.

C4d binding correlated with strong HLA antibodies involved in graft failures.

Early kidney graft size and Doppler parameters are associated with kidney graft function 1 year after transplantation.

Low-dose steroid maintenance for renal transplant recipients.

Cyclosporine and mycophenolate mofetil 48 hours before renal transplantation enables the use of low cyclosporine doses and achieves better graft function.

The effect of later change or modulation of immunosuppression on long-term renal transplant results.

Long-term outcome of very early cyclosporine minimization and de novo everolimus therapy in kidney transplant recipients: a pharmacokinetic guided approach.

Pretransplant soluble CD30 serum concentration does not affect kidney graft outcomes 3 years after transplantation.

Improvement of graft function after conversion to once daily tacrolimus of stable kidney transplant patients.

Neither mycophenolate acyl-glucuronide levels nor their areas under the curve are responsible for the gastrointestinal side effects in kidney transplant recipients receiving EC-MPA: a prospective trial.

The long-term outcomes of transplantation of kidneys with multiple renal arteries.

One-year follow-up of kidney transplant recipients with increased expression of mRNA for granzyme B in urinary cells.

Evaluation of arterial stiffness after successful renal transplantation using brachial-ankle pulse wave velocity.

Subclinical left ventricular echocardiographic abnormalities 1 year after kidney transplantation are associated with graft function and future cardiovascular events.

Posttransplant diabetes mellitus: analysis of risk factors, effects on biochemical parameters and graft function 5 years after renal transplantation.

Risk factors for the development of new-onset diabetes mellitus in a living related renal transplant program.

The effect of hyperuricemia on endothelial biomarkers and renal function in kidney allograft recipients.

Treatment of hyperparathyroidism with cinacalcet in kidney transplant recipients.

Evaluation of a preemptive strategy for BK polyomavirus-associated nephropathy based on prospective monitoring of BK viremia: a kidney transplantation center experience.

Routine BK virus surveillance in renal transplantation--a single center's experience.

Adenovirus infection after kidney transplantation in Thailand: seasonal distribution and potential route of acquisition.

Incidence and risk factors for pulmonary mycosis in kidney transplantation.

Liver transplantation in a randomized controlled trial of emergency treatment of acutely bleeding esophageal varices in cirrhosis.

Japanese-style intensive medical care improves prognosis for acute liver failure and the perioperative management of liver transplantation.

Liver recipient survival rate before and after model for end-stage liver disease implementation and use of donor risk index.

Large benign hepatocellular nodules in cirrhosis due to chronic venous outflow obstruction: diagnostic confusion with hepatocellular carcinoma.

Pretransplant hyponatremia could be associated with a poor prognosis after liver transplantation.

Evaluation of blood glucose levels after hepatitis B immune globulin administration utilizing two different blood glucose monitoring systems.

Living-donor liver transplantation in 126 patients with biliary atresia: single-center experience.

Steroid withdrawal in adult liver transplantation: occurrence at a single center.

Comparison of the affinity column-mediated immunoassay and microparticle enzyme immunoassay methods as a tacrolimus concentration assay in the early period after liver transplantation.

The use of hepatitis B core antibody-positive donor livers does not appear to have a deleterious effect on graft survival in liver transplantation for hepatitis C.

The influence of alcohol abuse history on the differential, longitudinal patterns of mental and physical quality of life following liver transplantation.

Predictors of high intraoperative blood loss derived by simple and objective method in adult living donor liver transplantation.

The comparison of the perioperative changes in lactate and prothrombin time between deceased versus living donor liver transplantation.

Biliary tract complications after orthotopic liver transplantation: still the 'Achilles heel'?

The effects of gabexate mesilate on the microsurgical reconstruction of the hepatic artery in living donor liver transplantation.

Use of the hilar plate looping technique for bile duct dissection in living donor liver transplantation significantly reduces recipient biliary complications.

Postoperative bleeding after AB0-incompatible living donor kidney transplantation.

Survival after liver transplantation in patients who develop renal insufficiency.

Rifle criteria for acute kidney dysfunction following liver transplantation: incidence and risk factors.

The impact of donor race on recurrent hepatitis C after liver transplantation.

Epstein-Barr virus infection after pediatric living-related liver transplantation--management and risk factors.

The impact of postoperative infection on long-term outcomes in liver transplantation.

Correlations between A/H1N1 influenza and acute cellular rejection in liver transplantation patients.

Procalcitonin in the setting of complicated postoperative course after liver transplantation.

Noncompliance with medications in pediatric patients after living-donor liver transplantation.

Simultaneous kidney-pancreas transplantation for end-stage renal disease patients with insulin-dependent diabetes and detectable C-peptide.

Factors influencing outcome of simultaneous kidney and pancreas transplantation: a 23-year single-center clinical experience.

Can the preprocurement pancreas suitability score predict ischemia-reperfusion injury and graft survival after pancreas transplantation?

Incidence and treatment of pancreatic fistula after simultaneous pancreas kidney transplantation.

Surgical protocol involving the infusion of paramagnetic microparticles for preferential incorporation within porcine islets.

Actions of the Japanese Pancreas and Islet Transplantation Association regarding transplanted human islets isolated using Liberase HI.

Magnetic resonance imaging study of mouse islet allotransplantation.

Effects of cyclooxygenase-2 inhibitor and adenosine triphosphate-sensitive potassium channel opener in syngeneic mouse islet transplantation.

Manufacturing of insulin-secreting spheroids with the RIN-5F cell line using a shaking culture method.

Emergency heart transplantation outcome: the Italian experience.

Cardiac allograft rejection correlates with increased expressions of Toll-like receptors 2 and 4 and allograft inflammatory factor 1.

Increased adherence after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation: a pre-experimental study.

Proton pump inhibitor co-medication reduces active drug exposure in heart transplant recipients receiving mycophenolate mofetil.

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Prevalence of chronic kidney disease in orthotopic heart transplant recipients and kidney allograft recipients using the new Chronic Kidney Disease Epidemiology Collaboration formula.

Anemia in heart and kidney allograft recipients: is there a role for hepcidin?

Copeptin in relation to New York Heart Association class in heart transplant recipients and kidney transplant recipients.

Blood pressure control in orthotopic heart transplant and kidney allograft recipients is far from satisfactory.

Association between panel reactive antibodies and acute small bowel rejection: analysis of a series of 324 intestinal transplants.

Outstanding survival and regeneration process by the use of intelligent acellular dermal matrices and mesenchymal stem cells in a burn pig model.

The role of liver stromal cells in dendritic cells development in mice.

Lymphangiogenesis associated with acute cellular rejection in rat liver transplantation.

Impact of graft type on remnant liver regeneration: right hepatectomy versus extended right hepatectomy.

An unusual presentation of a Page kidney 24 days after transplantation: case report.

Challenges in the Diagnosis of 2009 H1N1 in a Lung Transplant Patient and the Long-Term Implications for Prevention and Treatment: A Case Report

Attitude of the Omani population toward organ transplantation.

Short- and long-term outcomes of living donors in Tunisia: a retrospective study.

(AT) repeat in the 3' untranslated region of the CTLA-4 gene and susceptibility to acute allograft rejection in Tunisian renal transplantation.

MICA gene polymorphism in kidney allografts and possible impact of functionally relevant variants.

Complicated lymphoceles after kidney transplantation.

A novel surgical technique for management of vesicoureteral reflux following kidney transplantation: prospective study of 12 cases.

Sublingual tacrolimus as an alternative to intravenous route in patients with thoracic transplant: a retrospective study.

Combined pancreatic islets-lung transplantation in cystic fibrosis-related diabetes: case reports.

Cyclosporine inhibits profibrotic effects of interleukin-4 and transforming growth factor ß on human intrahepatic fibroblasts cultured in vitro.

Injection of donor-derived splenic dendritic cells plus a nondepleting anti-CD4 monoclonal antibody to prolong primary skin graft survival indefinitely and abrogate the production of donor-specific antibodies in the Fischer-to-Lewis rat combination.

Eculizumab: safety and efficacy after 17 months of treatment in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome: case report.

Epstein-Barr virus-associated hepatic leiomyosarcoma after renal transplantation: case report.

Nocardia carnea infection in a kidney transplant recipient.

Organ donation in Belgium 2009: 20% of donation after cardiocirculatory death.

Contribution of donors after cardiac death to the deceased donor pool: 2002 to 2009 University of Liege experience.

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Posttransplantation diabetes mellitus: a long-term retrospective cohort study.

Acute femoral neuropathy: a rare complication after renal transplantation.

Renal transplantation from living related donors: a single center experience in Viet Nam.

The multicenter Belgian survey on liver transplantation for hepatocellular failure after bariatric surgery.

Outcomes of long-term administration of intravenous hepatitis B immunoglobulins for the prevention of recurrent hepatitis B after liver transplantation.

Early arterial revascularization after hepatic artery thrombosis may avoid graft loss and improve outcomes in adult liver transplantation.

Air embolism during liver procurement: an underestimated phenomenon? A pilot experimental study.

Diagnostic value of antibodies against Pseudomonas aeruginosa in bronchoalveolar lavage fluid after lung transplantation.

Living related intestinal transplantation for Churg-Strauss syndrome: a case report.

Scandiatransplant report 2009.

Procedures and criteria for accepting the renal patient for inclusion on the waiting list for kidney transplantation in the Nordic countries.

What are we waiting for? Analyses of factors influencing cold ischemia time.

Conversion from calcineurin inhibitor to either mycophenolate mofetil or sirolimus improves renal function in liver transplant recipients with chronic kidney disease: results of a prospective randomized trial.

Long-term follow-up of living liver donors.

Surgical complications accompanying liver transplantation in Estonia.

Control of early Aspergillus mortality after lung transplantation: outcome and risk factors.

Natural killer group 2 member D cell recruitment driven by major histocompatibility complex class I chain-related antigens A and B: a possible mechanism during acute intestinal allograft rejection in the mouse.

The practical, moral, and ethical considerations of the new Israeli law for the allocation of donor organs.

Seropositive abdominal and thoracic donor organs are largely underutilized.

S-nitroso-N-acetylcysteine: a promising drug for early ischemia/reperfusion injury in rat liver.

B-type natriuretic peptide pretreatment attenuates heart ischemia-reperfusion injury in rats.

Association between interleukin-3 gene polymorphism and acute rejection after kidney transplantation.

Interferon-Î³ +874 polymorphism in the first intron of the human interferon-Î³ gene and kidney allograft outcome.

Why rejections are not biopsy proven: frequency and reasons.

Aspergillus spondylodiscitis in solid organ transplant recipients.

Individualizing early use of sirolimus in renal transplantation.

Steroid avoidance in two-haplotype-matched living donor renal transplants with basiliximab induction therapy.

Diagnostic performance of serum cystatin C and serum creatinine in the prediction of chronic kidney disease in renal transplant recipients.

Analytical performance of the Abbott Architect i2000 tacrolimus assay in Chinese patients after renal transplantation.

Possible defect of T suppressor cell subpopulation in patients with kidney acute rejection.

Rifaximin for the treatment of hepatic encephalopathy.

Hepatectomy-related hypophosphatemia may predict donor liver dysfunction in live-donor liver transplantation.

Dual grafts live donor liver transplantation for acute-on-chronic hepatitis B liver failure.

Management of intra-abdominal drain after living donor liver transplantation.

Dual left lobe living donor liver transplantation using donors unacceptable for right lobe donation: a case report.

Availability of anesthetic effect monitoring: utilization, intraoperative management and time to extubation in liver transplantation.

Interleukin-2 receptor antagonists in liver transplantation: a meta-analysis of randomized trials.

Results of a two-center study comparing hepatic fibrosis progression in HCV-positive liver transplant patients receiving cyclosporine or tacrolimus.

Prognostic and developmental factors in patients receiving liver transplant due to hepatocellular carcinoma: one center's experience in the north of Spain.

Treating hepatocellular carcinoma with sorafenib in liver transplant patients: an initial experience.

Total tumor volume predicts recurrence of hepatocellular carcinoma after liver transplantation in patients beyond Milan or UCSF criteria.

Self-expanding metallic stent placement with laryngeal mask in lung transplant recipients.

Black hairy tongue after allogeneic stem cell transplantation: an unrecognized cutaneous presentation of graft-versus-host disease.

Liver transplantation for severe hepatic graft-versus-host disease in two children after hematopoietic stem cell transplantation.

AFT024 cell line in co-culture system using high pore density insert (HPDI) maintains hematopoietic stem/progenitor cells (HSCs/HPCs) as more primitive state through histone modification.

Taurine supports preservation of proendocrine cell types in human umbilical cord blood-derived mononuclear cells during cryostorage.

Effects of a cGMP-specific phosphodiesterase inhibitor on expression of endothelial nitric oxide synthase and vascular endothelial growth factor in rats with cyclosporine-induced nephrotoxicity.

Transfection of hairpin small interfering RNA expression vector targeting rat nuclear factor (NF) (κB) inhibits rat cell proliferation induced by NF-κB signal pathway activation.

Preservation of islet survival by upregulating 3 integrin signaling: the importance of 3-dimensional islet culture in basement membrane extract.

Administration of probiotics reduces bacterial translocation after intestinal transplantation in rats.

Inhibition of swine leukocyte antigen-I presentation in transgenic mini-pig cell lines by expressing human cytomegalovirus US6.

Nasopharyngeal T-cell monomorphic posttransplant lymphoproliferative disorders and combined IgA nephropathy and membranous glomerulonephritis in a patient with renal transplantation: a case report with literature review.

Intractable recurrent hepatitis A virus infection requiring repeated liver transplantation: a case report.

Transcatheter aortic valve implantation in a heart transplant recipient: a case report.

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Effects of a cGMP-specific phosphodiesterase inhibitor on expression of endothelial nitric oxide synthase and vascular endothelial growth factor in rats with cyclosporine-induced nephrotoxicity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, J. W. Han, S. T. Kim, Y. S. Song, S. H. Kim, B. R. Eom, M. S. Jung, S. H. Choi, S. O. Han, B. G.
Description	Author Affiliation: Yang JW ( Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju, Gangwon, Korea.)
Abstract	BACKGROUND: The mechanism of cyclosporine (CsA)-induced nephrotoxicity has been suggested to be vasoconstriction due to reduced nitric oxide (NO), providing tissue fibrosis by elevation of transforming growth factor beta and vascular endothelial growth factor (VEGF). In this study using a rat model of CsA-induced nephrotoxicity, we administered a phosphodiesterase-5 inhibitor to ameliorate the renal injury and alter the expression of endothelial No synthase (eNOS) and VEGF. METHODS: A right nephrectomy was performed in Sprague-Dawley rats (n = 30; 200-250 g, all male). The Ischemia group (n = 6) underwent ligation of the left renal artery for 45 minutes (IR) before observation for 28 days. After IR, the udenafil group (n = 6) was treated with 10 mg/kg drug orally, the CsA group (n = 6) received 15 mg/kg CsA injected subcutaneously and the CsA plus udenafil group (n = 6) received 15 mg/kg CsA injected subcutaneously together with the oral administration of 10 mg/kg udenafil. RESULTS: Administration of udenafil significantly decreased serum creatinine either alone (0.21 ± 0.04 mg/dL) or in combination with CsA (1.86 ± 0.35 mg/dL) versus the ischemia (0.85 ± 0.22 mg/dL) and the CsA alone (3. 10 ± 0.77 mg/dL) group. (P = .002; P = .002). Comparing the Hematoxylin-eosin staining of the ischemia (0.41 ± 0.09) and CsA (0.44 ± 0.08) groups showed a significantly decreased loss of nuclei in proximal tubules after the administration of udenafil (0.27 ± 0.05 [P = .004] and 0.26 ± 0.02 [P = .002] respectively). Immunohistochemical staining showed strong eNOS staining in the udenafil and CsA plus udenafil groups. Western blots for eNOS showed decreased expression in the CsA group and increased expression in the udenafil group. Western blots for VEGF revealed reduced expression only in the CsA plus udenafil group. eNOS mRNA was decreased in the CsA (0.017 ± 0.010) compared with the ischemia group (0.048 ± 0.015; P = .000). VEGF mRNA which was decreased in the CsA group (2.026 ± 1.109), showed greater tendency after administration of udenafil (0.440 ± 0.449) (P = .003). CONCLUSION: The phosphodiesterase inhibitor ameliorated renal injury in a rat model of CsA-induced nephrotoxicity, possibly related to increased eNOS and reduced VEGF expression.
File Format	HTM / HTML
ISSN	00411345
Issue Number	10
Volume Number	42
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Cyclic Gmp Metabolism Cyclosporine Adverse Effects Kidney Drug Effects Nitric Oxide Synthase Type Iii Phosphodiesterase Inhibitors Pharmacology Vascular Endothelial Growth Factor A Animals Blood Urea Nitrogen Blotting, Western Creatinine Blood Immunohistochemistry Enzymology Male Polymerase Chain Reaction Rats Rats, Sprague-dawley Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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