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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lefer, A. M. Campbell, B. Chuhran, C. |
| Description | Author Affiliation: Campbell B ( Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107-6799, USA.) |
| Abstract | Endothelial dysfunction and loss of nitric oxide (NO) is an integral part of the initiation and maintenance of the inflammatory process such as that occurring in traumatic shock, and is considered responsible for much of the trauma induced microvascular injury. We investigated the effects of a vascular endothelial growth factor (VEGF) in a rat model of traumatic shock. Pentobarbital-anaesthetized rats subjected to Noble-Collip drum trauma developed a shock state characterized by marked hypotension and a 93% mortality rate with a mean survival time of 108+/-10 min in 14 rats. Accompanying these effects was a significant degree of endothelial dysfunction and a markedly elevated intestinal myeloperoxidase (MPO) activity. Treatment with 125 microg kg(-1) VEGF administered intravenously 18 h pre-trauma, increased survival rate to 67% (P<0.01), and prolonged survival time to 252+/-24 min in 12 rats (P<0.01). VEGF also significantly preserved the endothelium-dependent relaxation to ACh indicating a preservation of endothelium-derived NO. Our results indicate that endothelial dysfunction with its accompanying loss of NO plays an important role in tissue injury associated with trauma, and that preservation of NO is beneficial in traumatic shock. The mechanisms of the protective effect of VEGF in trauma involves preservation of eNOS function and diminished neutrophil accumulation resulting in reduced neutrophil-mediated tissue injury. British Journal of Pharmacology (2000) 129, 71 - 76 |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 129 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2000-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Endothelial Growth Factors Therapeutic Use Lymphokines Shock, Traumatic Drug Therapy Animals Blood Pressure Drug Effects Endothelium, Vascular Physiopathology Homeostasis Physiology In Vitro Techniques Intestines Enzymology Mesenteric Artery, Superior Muscle, Smooth, Vascular Neutrophil Infiltration Nitric Oxide Synthase Metabolism Nitric Oxide Synthase Type III Peroxidase Rats, Sprague-Dawley Mortality Survival Analysis Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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