NDLI: Impact of pretransplant human leukocyte antigen-C and -DP antibodies on kidney graft outcome.

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Impact of pretransplant human leukocyte antigen-C and -DP antibodies on kidney graft outcome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gilbert, M. Paul, S. Perrat, G. Giannoli, C. Pouteil Noble, C. Morelon, E. Rigal, D. Dubois, V.
Description	Country affiliation: France Author Affiliation: Gilbert M ( Histocompatibility Laboratory, Etablissement Français du Sang Rhône-Alpes, Lyon, France.)
Abstract	The aim of our study was to determine whether the presence of specific human leukocyte antigen (HLA)-C and -DP antibodies before transplantation influenced graft outcomes in immunized recipients. Two groups of pretransplant immunized recipients were studied: patients with only classical HLA-A, -B, -DR, -DQ antibodies (n = 176) and those with classical plus HLA-C and/or -DP antibodies (n = 27). Acute antibody-mediated rejection was preferentially associated with the presence of pretransplant anti-HLA-C and -DP antibodies (5/6 cases). In four cases, acute rejection episodes were followed by graft loss within 15 months after transplantation. There was a significant increase in the number of acute rejection episodes especially antibody-mediated acute rejections (P = .036) and in the number of graft losses for immunologic reasons (P < .001) among the group with pretransplant anti-C and -DP antibodies. Pretransplant anti-DP antibodies seemed to be involved more frequently in poor graft outcomes as shown in several recent published cases. We need to investigate their specific role among a larger cohort, taking into account an epitope analysis.
File Format	HTM / HTML
ISSN	00411345
Issue Number	9
Volume Number	43
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2011-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Hla-c Antigens Metabolism Hla-dp Antigens Kidney Transplantation Methods Renal Insufficiency Immunology Therapy Antibodies Chemistry Epitopes Flow Cytometry Graft Rejection Graft Survival Histocompatibility Testing Humans Polymerase Chain Reaction Polymorphism, Genetic Treatment Outcome Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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