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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rigo, D. H. Ziraldo, L. Di Monte, L. Jimenez, M. P. Giotto, A. P. Gutierrez, L. Rodriguez, I. Orias, M. Novoa, P. A. |
| Description | Country affiliation: Argentina Author Affiliation: Rigo DH ( Department of Nephrology, Sanatorio Allende, Córdoba City, Argentina. diegohrigo@gmail.com) |
| Abstract | INTRODUCTION: End-stage renal disease (ESRD) is a prevalent, important cause of death. Transplantation increases survival and improves the quality of life of patients with ESRD while long-term dialysis is related to poor outcomes even among patients who undergo subsequent transplantations. OBJECTIVES: To compare the advantages of preemptive procedures with kidney transplants among patients on renal replacement therapy. METHODS: This retrospective study was performed in two Córdoba city transplantation centers. Patients were divided into three groups: preemptive kidney transplant (PKT), patients on hemodialysis who received living donor kidney transplants (LDT), and subjects who received grafts from deceased donors (DDT). Serum creatinine, delayed graft function (DGF), subclinical rejection, and interstitial fibrosis/tubular atrophy (IF/TA) were evaluated at 6 months. RESULTS: Eighty patients were included: PKT (n = 28), LDT (n = 27), DDT (n = 25) mean age 29, 30, and 35 years, respectively. Women predominated among PKT and men in the other groups. In all groups, cyclosporine was the calcineurin inhibitor mostly used. Creatinine at 6 months was lower in the living donor groups (1.26 mg/dL PKT and 1.32 mg/dL LDT; P = NS) in relation to the deceased donor group (1.96 mg/dL; P < .05). DDT had the highest rate of DGF: 44% DDT versus 11.5% LDT vs 0% PKT (P < .05). Subclinical rejection was significantly lower among preemptive transplantations: PKT 7.6% versus LDT 18.5% versus DDT 24% (P < .05). IF/TA was higher in transplants from deceased donors: PKT 11.1%; LDT 11.5%; DDT 32%. CONCLUSIONS: Preemptive kidney transplantation offered the advantages of a lower creatinine, no DGF, as well as a reduced incidence of subclinical rejection and chronic allograft nephropathy at 6 months posttransplantation. |
| File Format | HTM / HTML |
| ISSN | 00411345 |
| Issue Number | 9 |
| Volume Number | 43 |
| e-ISSN | 18732623 |
| Journal | Transplantation Proceedings |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation__semicolon__medicine Kidney Failure, Chronic Therapy Kidney Transplantation Methods Adult Calcineurin Pharmacology Cyclosporine Female Graft Rejection Graft Survival Humans Living Donors Male Renal Dialysis Renal Replacement Therapy Retrospective Studies Tissue And Organ Procurement Transplantation, Homologous Treatment Outcome Journal Article Multicenter Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Surgery |
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