NDLI: Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance.

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Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance.

Immunology mini-review: the basics of T(H)17 and interleukin-6 in transplantation.

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Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Boyman, O. Krieg, C. Letourneau, S. Webster, K. Surh, C. D. Sprent, J.
Description	Country affiliation: Switzerland Author Affiliation: Boyman O ( Laboratory of Applied Immunobiology, University of Zurich, Zurich, Switzerland.)
Abstract	The biological activity of interleukin (IL)-2 and other cytokines in vivo can be augmented by binding to certain anti-cytokine monoclonal antibodies (mAb). Here, we review evidence on how IL-2/anti-IL-2 mAb complexes can be used to cause selective stimulation and expansion of certain T-cell subsets. With some anti-IL-2 mAbs, injection of IL-2/mAb complexes leads to expansion of CD8 T effector cells but not CD4 T regulatory cells (Tregs); these complexes exert less adverse side effects than soluble IL-2 and display powerful antitumor activity. Other IL-2/mAb complexes have minimal effects on CD8 T cells but cause marked expansion of Tregs. Preconditioning mice with these complexes leads to permanent acceptance of MHC-disparate pancreatic islets in the absence of immunosuppression.
File Format	HTM / HTML
ISSN	00411345
Issue Number	4
Volume Number	44
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Antibodies, Monoclonal Administration & Dosage Cell Proliferation Interleukin-2 Islets Of Langerhans Transplantation Immunology Lymphocyte Activation T-lymphocyte Subsets Transplantation Conditioning Methods Transplantation Tolerance Animals Cd8-positive T-lymphocytes Cancer Vaccines Graft Rejection Prevention & Control Graft Survival Histocompatibility Injections Mice Neoplasms Therapy T-lymphocytes, Regulatory Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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