NDLI: The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

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The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

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The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lafferty, K. J. Wang, Y. Gill, R. G. La Rosa, F. G. Pontesilli, O.
Description	Author Affiliation: Wang Y ( Barbara Davis Center for Childhood Diabetes, Denver, CO.);
Abstract	Spontaneous development of diabetes in the nonobese diabetic (NOD) mouse is mediated by an immunological process. In disease-transfer experiments, the activation of diabetes has been reported to require participation of both CD4+ and CD8+ T-cell subsets. These findings seem to indicate that the CD4+ cells are the helper cells for the activation of cytotoxic CD8+ cells that directly destroy islet beta cells in type I diabetes. In this report we challenge this interpretation because of two observations: (i) Destruction of syngeneic islet grafts by spontaneously diabetic NOD mice (disease recurrence) is CD4+ and not CD8+ T-cell dependent. (ii) Disease recurrence in islet tissue grafted to diabetic NOD mice is not restricted by islet major histocompatibility complex antigens. From these observations we propose that islet destruction depends on CD4+ effector T cells that are restricted by major histocompatibility complex antigens expressed on NOD antigen-presenting cells. Both of these findings argue against the CD8+ T cell as a mediator of direct islet damage. We postulate that islet damage in the NOD mouse results from a CD4+ T-cell-dependent inflammatory response.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, CD4 Immunology Antigens, Differentiation, T-Lymphocyte Diabetes Mellitus, Experimental Surgery Graft Survival Islets Of Langerhans Transplantation T-Lymphocytes Animals Antibodies, Monoclonal Isolation & Purification Antigens, CD8 Genetics Pathology Lymphocyte Depletion Mice Mice, Mutant Strains Models, Biological T-Lymphocyte Subsets Thyroid Gland Transplantation Transplantation, Homologous Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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