NDLI: Systemic decellularization for multi-organ scaffolds in rats.

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Evolution of registry and tracking system for organ transplantation in Japan.

Difficulties in organ procurement and transplantation in the aboriginal minority people in Taiwan.

The dilemma of 'to be or not to be': developing electronically e-health & cloud computing documents for overseas transplant patients from Taiwan organ transplant health professionals' perspective.

National survey of Filipinos on acceptance of incentivized organ donation.

Outcomes of management for potential deceased donors.

Professional education and hospital development for organ donation.

Modification of the education system for organ procurement coordinators in Japan after the revision of the Japanese Organ Transplantation Act.

A newly developed container for safe, easy, and cost-effective overnight transportation of tissues and organs by electrically keeping tissue or organ temperature at 3 to 6°C.

A study on knowledge and attitude toward brain death and organ retrieval among health care professionals in Korea.

Kidney transplantation from donation after cardiac death donors in China--a single-center experience.

The fate of patients on the waiting list for lung transplantation in Korea.

Donor evaluation for lung transplantation in Korea.

Relationship between postoperative lung atelectasis and position of the endotracheal tube in pediatric living-donor liver transplantation.

Extracorporeal membrane oxygenation and Thoratec pneumatic ventricular assist devices as double bridge to heart transplantation.

The influence of the organ allocation policy on a patient's chances of undergoing heart transplantation and the posttransplantation survival rate.

Ventricular assist device application as a bridge to pediatric heart transplantation: a single center's experience.

Combined St. Thomas and histidine-tryptophan-ketoglutarat solutions for myocardial preservation in heart transplantation patients.

The outcome of heart transplantation in hepatitis C-positive recipients.

Endomyocardial biopsy in heart transplantation: schedule or event?

Cardiac allograft vasculopathy compared by intravascular ultrasound sonography: everolimus to mycophenolate mofetil--one single-center experience.

Steroid pulse therapy combined with plasmapheresis for clinically compromised patients after heart transplantation.

Isolated cardiac sarcoidosis in heart transplantation.

Clinical experience of tacrolimus with everolimus in heart transplantation.

Twenty-four year single-center experience of hepatitis B virus infection in heart transplantation.

Heart retransplantation for pediatric primary allograft failure.

Changes in health-related quality of life across three post-heart transplantation stages: preoperative extracorporeal membrane versus non-extracorporeal membrane group/clinical trial plan group versus non-clinical trial plan group in Taiwan.

Role of killer immunoglobulin-like receptor-ligand interactions in human leukocyte antigen-matched sibling hematopoietic stem cell transplantation.

Audit of peripheral stem cell transplantation for aplastic anemia in multitransfused infected patients.

Single-center experience with pancreas transplantation.

Inducible cyclooxygenase expression mediating hypoxia/reoxygenation-induced pulmonary vasoconstriction is attenuated by a cyclooxygenase inhibitor in rats.

L-ascorbic acid and alpha-tocopherol attenuates liver ischemia-reperfusion induced of cardiac function impairment.

The role of CD14 and Toll-like receptor 4 of Kupffer cells in hepatic ischemia-reperfusion injury in rats.

A basic consideration for porcine liver preservation using a novel continuous machine perfusion device.

Functional recovery of donation after cardiac death liver graft by continuous machine perfusion preservation in pigs.

Protective role of nitric oxide induced by ischemic preconditioning on cold ischemic-reperfusion injury of rat liver graft.

The effect of perfusion speed on graft reperfusion injury after rat orthotopic liver transplantation.

Quantification of macrovesicular and microvesicular hepatic steatosis in rats using 3.0-T ¹H-magnetic resonance spectroscopy.

Pretransplant screening and evaluation of liver graft viability using machine perfusion preservation in porcine transplantation.

Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats.

Liver reperfusion-induced decrease in dynamic compliance and increase in airway resistance are ameliorated by preischemic treatment with melatonin through scavenging hydroxyl radicals in rat lungs.

Preischemic treatment with melatonin attenuates liver reperfusion-induced impairment of cardiac function.

The protective effect of curcumin on ischemia-reperfusion-induced liver injury.

Protective role of Shenfu on ischemia-reperfusion injury of rat liver grafts.

Apoptosis in endothelial cells by cyclosporine.

Effect of cyclosporine on apoptosis in bronchial epithelial cells.

Effects of cyclosporine on oxidative stress in human bronchial epithelial cells.

Effects of cyclosporine on metalloproteinase in endothelial cells.

Tumor necrosis factor- pathway plays a critical role in regulating interferon-Î³ induced protein-10 production in initial allogeneic human monocyte-endothelial cell interactions.

Monocyte-derived CD40 expression is regulated by interferon-Î³/interferon-Î³ receptor-1 pathway when acting as a bridge during their interaction with T cells and allogeneic endothelial cells.

A novel cannulation technique for isolation of human hepatocytes from explanted diseased whole livers.

Slow cooling rate with a shock cooling program can effectively cryopreserve pig hepatocytes.

Cryopreservation of immobilized rat hepatocytes for the development of a bioartificial liver system.

Effect of fulminant hepatic failure porcine plasma supplemented with essential components on encapsulated rat hepatocyte spheroids.

Potentiality of immobilized pig hepatocyte spheroids in bioartificial liver system.

Effect of spheroid aggregation on susceptibility of primary pig hepatocytes to cryopreservation.

Self-organization of human hepatic organoid by recapitulating organogenesis in vitro.

High glucose increases mesangial lipid accumulation via impaired cholesterol transporters.

Fractalkine increases mesangial cell proliferation through reactive oxygen species and mitogen-activated protein kinases.

Lipopolysaccharide increases monocyte binding to mesangial cells through fractalkine and its receptor.

Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance.

Immunology mini-review: the basics of T(H)17 and interleukin-6 in transplantation.

The role of invariant NKT cells in liver transplant tolerance in rats.

Dynamic changes of indoleamine 2,3-dioxygenase of Kupffer cells in rat liver transplant rejection and tolerance.

Can immune function assay predict infection or recovery?

Immunomodulation of human CD8âº T cells by thymoglobulin in vitro.

Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4âº CD25âº Foxp3âº regulatory T cells in vitro.

CD28 superagonist antibody treatment attenuated obliterative bronchiolitis in rat allo-orthotopic tracheal transplantation by preferentially expanding Foxp3-expressing regulatory T cells.

Induction of regulatory CD4âº cells and prolongation of survival of fully allogeneic murine cardiac grafts by danazol.

The smell of Tokishakuyaku-san (TJ-23) induces generation of regulatory T cells and prolongation of survival of fully allogeneic cardiac grafts in mice.

Artemisiae capillaris herba induces prolonged survival of fully cardiac allografts and generates regulatory cells in mice.

Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4âº cells in mice.

The antiproteinuric effects of green tea extract on acute cyclosporine-induced nephrotoxicity in rats.

Cellular function of RhoGDI- mediates the cycling of Rac1 and the regulation of pancreatic beta cell death.

Alpha-melanocyte stimulating hormone preserves islet graft survival through down-regulation of Toll-like receptors.

Microencapsulation of pancreatic islets with canine ear cartilage for immunoisolation.

Hybrid cellular spheroids from hepatocellular carcinoma and insulin-secreting cell lines.

Impact of coculture with ischemic preconditioned hepatocellular carcinoma cell line (Hep-G2) cells on insulin secreting function of rat insulin-secreting cell line (RIN-5F) cells.

Regenerative medicine approach as an alternative treatment to islet transplantation.

Stimulation of liver regeneration after hepatectomy in mice by injection of bone marrow mesenchymal stem cells via the portal vein.

The phenotypic characteristic of liver-derived stem cells from adult human deceased donor liver.

Differentiation and major histocompatibility complex antigen expression in human liver-derived stem cells.

Live cell-imaging perfusion culture system of liver sinusoidal endothelial cells to mimic stem cell engraftment in liver.

In vitro evaluation of migratory capacity of human liver stem cells influenced by soluble factors.

Delayed treatment with human umbilical cord blood-derived stem cells attenuates diabetic renal injury.

Highly efficient generation of definitive endoderm lineage from human induced pluripotent stem cells.

Generation of functional human vascular network.

A study of the glycoantigens of neonatal porcine islet-like cell clusters using a lectin microarray.

A cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase from porcine endothelial cells.

The interleukin-2 receptor chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.

Efficacy of double filtration plasmapheresis in removing xenoantibodies and prolonging xenograft survival in an ex vivo swine perfusion model.

Porcine bioengineered scaffolds as new frontiers in regenerative medicine.

Systemic decellularization for multi-organ scaffolds in rats.

A potent anti-angiogenic factor, vasohibin-1, ameliorates experimental bronchiolitis obliterans.

Human elastic cartilage engineering from cartilage progenitor cells using rotating wall vessel bioreactor.

Long-term viability of transplanted hybrid cellular spheroids within chondrocyte sheets.

Adenosine receptors are up-regulated in unilateral ureteral obstructed rat kidneys.

Mucosal protective effect of PGI2 on canine small bowel auto-transplantation.

Prosthetic endocarditis treated by repeated heart transplantation: report of a successful case.

Combined heart transplantation and total replacement of thoracic aorta in Marfan's syndrome with recurrent aortic dissection: a case report.

Total pancreatectomy combined with partial pancreas autotransplantation for recurrent pancreatic cancer: a case report.

Chronic rejection in a small bowel transplant with successful revision of the allograft by segmental resection: case report.

Year: 2012 Volume: 44 Issue: 3

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Systemic decellularization for multi-organ scaffolds in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Park, K. M. Woo, H. M.
Description	Author Affiliation: Park KM ( Stem Cell Institute-KNU, Kangwon National University, Chuncheon, Korea. oh_miracle@hanmail.net)
Abstract	INTRODUCTION: Bioscaffolds derived from animal organs are promising materials for xenotransplantation and regenerative medicine. For effective generation of biological scaffolds from diverse organs, there have been many technical challenges. In this study, we introduced a novel approach to create multiorgan bioscaffolds through systemic decellularization. METHODS AND MATERIALS: To obtain acellular bioscaffolds, the healthy adult rats were systemically perfused with ionic detergent through the carotid artery. Additional liver perfusion was set up to prevent potential obstruction from the influx of the decellularized debris via the portal vein. The perfusion system was controlled to maintain a constant physiological cardiac output of approximately 50 mL/min and was designed to minimize air entrapment. After decellularization, every organ designated for bioscaffold was harvested for evaluation of vascular structure and histology. RESULTS: The perfusion times were different for each organ. In our histological analysis, the decellularized bioscaffolds harvested from most organs including major solid organs (ie, heart, liver, and kidney) as well as the others (such as stomach, intestines, spleen, etc) represented no evidence of residual cellular materials. Furthermore, the well-preserved collagen materials and intact vascular structures were also confirmed. CONCLUSION: The results from this study suggested that this systemic decellularization has the advantages to obtain a variety of bioscaffolds from single donor, and we can even decellularize organs with complex influx vascular structures. This method may also be used to study organ bioengineering for patients who need simultaneous combined organ transplantation.
File Format	HTM / HTML
ISSN	00411345
Issue Number	4
Volume Number	44
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Heart Kidney Liver Tissue Engineering Methods Tissue Scaffolds Animals Graft Rejection Immunology Prevention & Control Graft Survival Heart Transplantation Blood Supply Cytology Kidney Transplantation Liver Transplantation Male Perfusion Radiography Rats Rats, Sprague-dawley Sodium Dodecyl Sulfate Transplantation, Heterologous Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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