NDLI: Everolimus monotherapy or combined therapy in liver transplantation: indications and results.

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Dendritic cells play an essential role in transplantation responses via myeloid differentiation factor 88 signaling.

Does hypothermic machine perfusion of human donor livers affect risks of sinusoidal endothelial injury and microbial infection? A feasibility study assessing flow parameters, sterility, and sinusoidal endothelial ultrastructure.

Impact of rewarming preservation by continuous machine perfusion: improved post-transplant recovery in pigs.

Temperature controlled machine perfusion system for liver.

Comparative analysis of in situ versus ex situ perfusion on micro circulation in liver procurement--an experimental trial in a porcine model.

Improvement of hepatocyte recovery from rat liver subjected to 1-hour warm ischemic injury by using citrate phosphate dextrose added to euro-collins perfusion solution.

The protective effect of ischemic preconditioning against hepatic ischemic-reperfusion injury under isoflurane anesthesia in rats.

The effect of mTOR-inhibition on NF-κB activity in kidney ischemia-reperfusion injury in mice.

Fluorescence spectroscopy in renal ischemia and reperfusion: noninvasive evaluation of organ viability.

The effect of HTK solution modification by addition of thyrotropin and corticotropin on biochemical indices reflecting ischemic damage to porcine kidney.

Histologic effects of University of Wisconsin two-layer method preservation of rat pancreas.

Gene expression changes in rat pancreas transplant model after long-term cold storage of the graft in perfluorohexyloctane.

New model of veno-venous bypass for management of anhepatic phase in experimental study on dogs.

Experimental liver autotransplantation with novel scheme of veno-venous bypass as a model of liver denervation and delymphatization.

Chronic antibody-mediated responses may mediate chronic rejection in rat orthotopic liver transplantation.

Hepatic artery reconstruction prevents ischemic graft injury, inhibits graft rejection, and mediates long-term graft acceptance in rat liver transplantation.

Acute rejection after swine leukocyte antigen-matched kidney allo-transplantation in cloned miniature pigs with different mitochondrial DNA-encoded minor histocompatibility antigen.

Evaluation by fluorescence spectroscopy of the most appropriate renal region for obtaining biopsies: a study in the rat.

Expression of receptor activator of nuclear factor-kappa B ligand in leukocytes during acute kidney rejection after transplantation in rats.

Six-month feeding of low-dose fish oil decreases vascular expression of high mobility group box1 and receptor for advanced glycation end-products in rat chronic allograft vasculopathy.

Laparoscopic kidney orthotopic transplant: preclinical study in the pig model.

Serum apolipoprotein E as a marker to monitor graft function after hepatocyte transplantation in a clinically relevant mouse model.

Disparate hypervariable region-1 of mitochondrial DNA did not induce skin allograft rejection in cloned porcine models.

Prolongation of the rat composite tissue allograft survival by the combination of tolerogenic immature dendritic cells and short-term treatment with FK506.

Epithelial to mesenchymal transition in murine tracheal allotransplantation: an immunohistochemical observation.

Uterus transplantation model in sheep with heterotopic whole graft and aorta and cava anastomoses.

Posttransplantation systemic immunomodulation with SA-FasL-engineered donor splenocytes has robust efficacy in preventing cardiac allograft rejection in mice.

Transgenic pig expressing the red fluorescent protein kusabira-orange as a novel tool for preclinical studies on hepatocyte transplantation.

Long-term comparison of rat model of chronic allograft rejection of orthotopic small bowel transplantation induced by cyclosporine versus tacrolimus.

Plasticity and overlap of in vitro-induced regulatory T-cell markers in healthy humans.

Differences in the induction of induced human CD4(+) CD25(+) FoxP3(+) T-regulatory cells and CD3(+) CD8(+) CD28(-) T-suppressor cells subset phenotypes in vitro: comparison of phorbol 12-myristate 13-acetate/ionomycin and phytohemagglutinin stimulation.

Donor-specific regulatory T cells generated on donor B cells are superior to CD4+CD25high cells in controlling alloimmune responses in humanized mice.

Differences in alloimmune response between elderly and young mice.

In vitro effects of ATG-Fresenius on immune cell adhesion.

Mouse T cells engineered to display on their surface a novel form of FasL protein undergo apoptosis when stimulated with alloantigens: implications for graft-versus-host disease.

PD-L1 signal on liver dendritic cells is critical for Foxp3(+)CD4(+)CD25(+) Treg and liver tolerance induction in mice.

Practical and critical instruction for nonhuman primate diabetic models.

Porcine islet adaptation to metabolic need of monkeys in pig-to-monkey intraportal islet xenotransplantation.

Pancreatic transdifferentiation in porcine liver following lentiviral delivery of human furin-cleavable insulin.

Development of polyvinyl alcohol bioartificial pancreas with rat islets and mesenchymal stem cells.

Topographical arrangement of - and ß-cells within neo-islet tissues engineered by islet cell sheet transplantation in mice.

Proliferation and functional assessment of pseudo-islets with the use of pancreatic endocrine cells.

Immunomodulation with SA-FasL protein as an effective means of preventing islet allograft rejection in chemically diabetic NOD mice.

Effects of glucagon-like peptide 1 analogue on the early phase of revascularization of transplanted pancreatic islets in a subcutaneous site.

Intragraft mechanisms associated with the immunosuppressive versus the tolerogenic effect of CD3 antibodies in a mouse model of islet allografts.

Evaluation of total tumor volume and pretransplantation -fetoprotein level as selection criteria for liver transplantation in patients with hepatocellular cancer.

Higher serum methionine levels as a predictive factor in patients with irreversible fulminant hepatic failure.

Liver failure and the need for transplantation in 6 patients with hepatoportal sclerosis.

The long-term outcomes of patients transplanted due to acute liver failure with hepatic human herpesvirus-6 infection.

Postinterventional tumor necrosis predicts recurrence-free long-term survival in liver transplant patients with advanced hepatocellular carcinoma.

Comparison of mixed venous oxygen saturation after in vitro calibration of pulmonary artery catheter with that of pulmonary arterial blood in patients undergoing living donor liver transplantation.

Vecuronium requirements according to the operative phase during living donor liver transplantation under desflurane anesthesia.

The comparison of femoral and radial arterial blood pressures during pediatric liver transplantation.

Use of the recipient celiac trunk for hepatic artery reconstruction in orthotopic liver transplantation.

Efficiency of the LigaSure vessel sealing system for recipient hepatectomy in liver transplantation.

The optimal timing for preparation of recipient superficial femoral veins to minimize intraoperative blood loss in living donor liver transplantation.

Toward more than 400 liver transplantations a year at a single center.

More than 300 consecutive living donor liver transplants a year at a single center.

Right-lobe living-donor liver transplantation in adult patients with acute liver failure.

Liver transplantation for hepatitis B-induced liver disease: long-term outcome and effectiveness of antiviral therapy for prevention of recurrent hepatitis B infection.

Long-term outcome of liver transplantation as treatment modality in patients with hepatocellular carcinoma in cirrhosis: a single-center experience.

The diagnostic value of systolic acceleration time and resistive index as noninvasive modality for detection of graft rejection after orthotopic liver transplantation.

Pregnancy and orthotopic liver transplantation.

Induction therapy with alemtuzumab (campath) in combined liver-kidney transplantation: University of Bologna experience.

Everolimus monotherapy or combined therapy in liver transplantation: indications and results.

Conversion to prolonged-release tacrolimus for pediatric living related donor liver transplant recipients.

mTOR inhibition in liver transplantation: how to dose for effective/safe CNI reduction?

Supporting liver transplantation by clinical pathway intelligence.

The significance of antiphospholipid antibodies in liver recipients.

Factor V Leiden mutation is a risk factor for hepatic artery thrombosis in liver transplantation.

Risk factors for hepatic artery thrombosis after microsurgical vascular reconstruction in liver transplantation.

HHV-6: clinical and laboratory investigations and correlations with encephalitis in liver transplant recipients.

Clinical outcome in cardiac transplant recipients receiving tacrolimus retard.

Comparative performance evaluation of a donor-specific bead-based crossmatch technique for the detection of donor-specific anti-HLA antibodies in heart transplantation.

Vascular adhesion protein-1, a novel molecule, in kidney and heart allograft recipients.

Platelet factor 4-positive thrombi adhering to the ventricles of a ventricular assist device in patients with heparin-induced thrombocytopenia type II.

Improved survival in patients with continuous-flow ventricular assist device for bridge to heart transplantation.

Beyond islet transplantation in diabetes cell therapy: from embryonic stem cells to transdifferentiation of adult cells.

Ten years' evaluation of diet, anthropometry, and physical exercise adherence after islet allotransplantation.

A national survey of patients with intestinal motility disorders who are potential candidates for intestinal transplantation in Japan.

Mortality after steroid-resistant acute cellular rejection and chronic rejection episodes in adult intestinal transplants: report from a single center in induction/preconditioning era.

The renoprotective effect of bone marrow-derived endothelial progenitor cell transplantation on acute ischemia-reperfusion injury in rats.

Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of hypoxanthine-Guanine phosphoribosyltransferase short hairpin RNA confers chemoprotection against 6-thioguanine cytotoxicity.

Comparative analysis of T-cell depletion method for clinical immunotherapy-anti-hepatitis c effects of natural killer cells via interferon-Î³ production.

Utilizing glycogen synthase kinase-3ß as a marker for the diagnosis of graft-versus-host disease.

Isolation and hepatocyte differentiation of mesenchymal stem cells from porcine bone marrow--'surgical waste' as a novel MSC source.

Case report: maximum-intensity projection and minimum-intensity projection of computed tomography are helpful in the diagnosis of Budd-Chiari syndrome in complicated liver cirrhosis.

Accidental acetaminophen overdose results in liver transplant during second trimester of pregnancy: a case report.

A patient with hepatic artery thrombosis after living-donor liver transplantation survived the great East Japan earthquake 3 days after reoperation: a case report.

HLA antibody-incompatible kidney transplantation between jehovah's witnesses--a case report.

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Everolimus monotherapy or combined therapy in liver transplantation: indications and results.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Alegre, C. Jiménez, C. Manrique, A. Abradelo, M. Calvo, J. Loinaz, C. García-Sesma, A. Cambra, F. Alvaro, E. García, M. Sanabria, R. Justo, I. Caso, O. Moreno, E.
Description	Country affiliation: Spain Author Affiliation: Alegre C ( 12 de Octubre University Hospital, Madrid, Spain. doctora83@gmail.com)
Abstract	INTRODUCTION: Everolimus is a potent immunosuppressant with several advantages over calcineurin inhibitors, such as good tolerance, preventive effects on cardiovascular morbidity, and mortality and cancer prevention as it inhibits cell proliferation. PATIENTS AND METHODS: Between April 1986 and December 2010, we performed 1500 liver transplants (OLT) in 1341 recipients, including 57 patients who were prescribed everolimus 24 (42.1%) as monotherapy and 33 (57.9%) as treatments combined with other immunosuppressants. We performed a retrospective analysis of our experience with conversion to everolimus in OLT recipients. RESULTS: The 43 men and 14 women had a mean overall age at transplantation of 59.1 ± 10 years. The most frequent indication for OLT was hepatocellular carcinoma (HCC; 53.8%). Everolimus was introduced to prevent HCC recurrence (53%), development of de novo tumors (33%), address renal dysfunction (7%), or overcome side effects of other immunosuppressants (7%). We observed a significant improvement in renal function using the estimated glomerular filtration rate (Crockcroft-Gault formula) from 68.5 mL/min before to 74.5 mL/min after switching to everolimus. The 72% of recipients who developed ≥1 adverse event, most frequently showed hyperlipidemia (34.4%). CONCLUSION: Both monotherapy and combined everolimus regimens were well-tolerated immunosuppressive regimens in liver transplant recipients with recurrent or de novo malignancies. Everolimus improved renal function. The most common side effects were hyperlipidemia, edema, and mouth ulcerations, which were well controlled with anti-lipidemic agents or decreased everolimus dosages.
File Format	HTM / HTML
ISSN	00411345
Issue Number	5
Volume Number	45
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Immunosuppressive Agents Administration & Dosage Liver Transplantation Sirolimus Analogs & Derivatives Aged Carcinoma, Hepatocellular Surgery Drug Therapy, Combination Everolimus Female Humans Liver Neoplasms Male Middle Aged Journal Article
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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