NDLI: New model of veno-venous bypass for management of anhepatic phase in experimental study on dogs.

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New model of veno-venous bypass for management of anhepatic phase in experimental study on dogs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chkhaidze, Z. Khodeli, N. Pilishvili, O. Partsakhashvili, D. Jangavadze, M. Kordzaia, D.
Description	Country affiliation: Georgia Author Affiliation: Chkhaidze Z ( Department of Clinical Anatomy and Operative Surgery, A. Natishvili Institute of Morphology, I. Javakhishvili State University, Tbilisi, Georgia.)
Abstract	Blood is shunted from the inferior vena cava and portal vein to the superior vena caval system to prevent congestion in the lower parts of the body during the anhepatic phase (AP) of liver transplantation. It leads to overload in the superior vena caval system retarding cranial outflow due to a nonphysiological blood redistribution. To overcome this problem, we developed a new bypass in dogs: blood is shunted from the inferior (caudal) vena cava and portal vein to the suprahepatic inferior (caudal) vena cava. This model was compared with traditional one with or without a pump. Blood pressure and flow parameters were estimated during 3 hours of AP in four groups of four dogs each. The current study showed that a nontraditional scheme of venous bypass reduced circulatory complications during AP, especially in the cranial vena caval system, although a low rate of congestion remains in the caudal vena cava and portal vein systems. Whereas the same scheme using a pump effectively prevented congestion in all of the systems: cranial, caudal, and portal. We concluded that application of a nontraditional bypass scheme, providing venous blood return into suprahepatic part of caudal vena cava, can be considered to be a method of choice for experimental liver transplantation.
File Format	HTM / HTML
ISSN	00411345
Issue Number	5
Volume Number	45
e-ISSN	18732623
Journal	Transplantation Proceedings
Language	English
Publisher	Elsevier
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Transplantation__semicolon__medicine Extracorporeal Circulation Methods Liver Transplantation Models, Animal Animals Dogs Male Portal Vein Surgery Vena Cava, Inferior Vena Cava, Superior Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Transplantation Surgery

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