NDLI: CMOS-compatible silicon nanowire field-effect transistors for ultrasensitive and label-free microRNAs sensing.

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CMOS-compatible silicon nanowire field-effect transistors for ultrasensitive and label-free microRNAs sensing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lu, Na Gao, Anran Dai, Pengfei Song, Shiping Fan, Chunhai Wang, Yuelin Li, Tie
Description	Country affiliation: China Author Affiliation: Lu N ( State Key Laboratories of Transducer, Technology & Science and Technology on Micro-system Laboratory, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, 200050, Shanghai, China.)
Abstract	MicroRNAs (miRNAs) have been regarded as promising biomarkers for the diagnosis and prognosis of early-stage cancer as their expression levels are associated with different types of human cancers. However, it is a challenge to produce low-cost miRNA sensors, as well as retain a high sensitivity, both of which are essential factors that must be considered in fabricating nanoscale biosensors and in future biomedical applications. To address such challenges, we develop a complementary metal oxide semiconductor (CMOS)-compatible SiNW-FET biosensor fabricated by an anisotropic wet etching technology with self-limitation which provides a much lower manufacturing cost and an ultrahigh sensitivity. This nanosensor shows a rapid (< 1 minute) detection of miR-21 and miR-205, with a low limit of detection (LOD) of 1 zeptomole (ca. 600 copies), as well as an excellent discrimination for single-nucleotide mismatched sequences of tumor-associated miRNAs. To investigate its applicability in real settings, we have detected miRNAs in total RNA extracted from lung cancer cells as well as human serum samples using the nanosensors, which demonstrates their potential use in identifying clinical samples for early diagnosis of cancer.
File Format	HTM / HTML
ISSN	16136810
Issue Number	10
Volume Number	10
e-ISSN	16136829
Journal	Small
Language	English
Publisher	Wiley-VCH
Publisher Date	2014-05-28
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nanotechnology Lung Neoplasms Diagnosis Micrornas Analysis Genetics Nanowires Chemistry Silicon Transistors, Electronic Base Pair Mismatch Base Sequence Tumor Markers, Biological Biosensing Techniques Instrumentation Electric Conductivity Equipment Design Equipment Failure Analysis Humans Molecular Sequence Data Ultrastructure Reproducibility Of Results Sensitivity And Specificity Sequence Analysis, Rna Methods Staining And Labeling Tumor Cells, Cultured Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology

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