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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Galukande, Moses Wabinga, Henry Mirembe, Florence Karamagi, Charles Asea, Alexzander |
| Spatial Coverage | Uganda |
| Description | Country affiliation: Uganda Author Affiliation: Galukande M ( Department of Surgery, College of Health Sciences, Makerere University, Kampala, Uganda.); Wabinga H ( Department of Pathology, College of Health Sciences, Makerere University, Kampala, Uganda.); Mirembe F ( Department of Obstetrics and Gynecology, College of Health Sciences, Makerere University, Kampala, Uganda.); Karamagi C ( Clinical Epidemiology Unit, College of Health Sciences, Makerere University, Kampala, Uganda.); Asea A ( The Texas A & M Health Science Center College of Medicine, USA.) |
| Abstract | INTRODUCTION: Sub-Saharan Africa is predicted to face an unprecedented growth of cancers including breast cancer. There are indications of a significant burden of aggressive and late stage breast disease among premenopausal women in sub-Saharan Africa; because hormonal status tests are not routinely done, many women are given anti-hormonal therapy empirically. There is paucity of data on breast cancer molecular subtypes and their characteristics among women in sub Saharan Africa. The objective is to determine the prevalence of breast cancer molecular phenotypes among Ugandan women. METHODS: This was a cross sectional descriptive study, conducted at a tertiary hospital in Africa. Eligible participants' formalin fixed and paraffin embedded sections were evaluated. H & E stains and Immunochemistry (Estrogen Receptor (ER), Progesterone Receptor (PR), Human Epidermal growth factor Receptor (HER2)) were performed. Ethical approval was obtained. RESULTS: A total of 226 patient samples were evaluated. The mean age was 45 years (SD 14);the prevalence of Triple Negative Breast Cancer (TNBC) was 34% (77/226), Luminal A 38% (83/226), HER2 positive was 22% (49/226), and Luminal B was 5% (13/226). High-grade (III) tumors were 68%, stage III and IV constituted 75% of presentations. Histological type was mostly invasive ductal carcinoma. Most patients (55%) were from rural areas. CONCLUSION: Ugandan women had an over representation of TNBC and high-grade breast tumors. Underlying reasons ought to be investigated. The empirical use of tamoxifen (anti-hormonal therapy) should be reexamined. |
| File Format | HTM / HTML |
| e-ISSN | 19378688 |
| DOI | 10.11604/pamj.2014.17.249.330 |
| Journal | Pan African Medical Journal |
| Volume Number | 17 |
| Language | English |
| Publisher | African Field Epidemiology Network |
| Publisher Date | 2014-01-01 |
| Publisher Place | Uganda |
| Access Restriction | Open |
| Subject Keyword | Discipline Medicine Breast Neoplasms Pathology Carcinoma, Ductal, Breast Epidemiology Triple Negative Breast Neoplasms Adolescent Cross-sectional Studies Neoplasm Grading Neoplasm Staging Uganda Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
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