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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ben Salem, Chaker Badreddine, Atef Belajouza, Omar Belajouza, Colandane Ghariani, Najet Houssem, Hmouda |
| Spatial Coverage | Tunisia |
| Description | Country affiliation: Tunisia Author Affiliation: Ben Salem C ( Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Tunisia.); Badreddine A ( Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Tunisia.); Belajouza O ( Dermatology Ward, Farhat Hached University Hospital, Sousse, Tunisia.); Belajouza C ( Dermatology Ward, Farhat Hached University Hospital, Sousse, Tunisia.); Ghariani N ( Dermatology Ward, Farhat Hached University Hospital, Sousse, Tunisia.); Houssem H ( Medical Intensive Care, Medical Intensive Care Unit, Sahloul University Hospital, Sousse, Tunisia.) |
| Abstract | Toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, is a rare, life-threatening and wide-spread exfoliative disease of the skin and mucous membrane that is most commonly drug-induced. We retrospectively reviewed the charts of 17 patients who suffered from TEN in Farhat Hached University Hospital, Sousse, Tunisia over a 19-year period from January 1994 to January 2013. Causality for suspected drugs was assessed by means of the Naranjo adverse drug reaction (ADR) probability scale. Antibiotics, mainly ß-lactams, were the most common implicated drugs, followed by nonsteroidal anti-inflammatory drugs, anticonvulsants, and allopurinol. The interval between drug intake and onset of the first symptom ranged between few hours and 19 days with a mean period of 6.11 days. There was extensive skin detachment, averaging 66.17% of total body surface area (range 40-95%). The most major complication was infection, occurring in 9 patients (53%). Seven patients died with a mortality rate of 41%. |
| File Format | HTM / HTML |
| e-ISSN | 19378688 |
| DOI | 10.11604/pamj.2014.19.269.3987 |
| Journal | Pan African Medical Journal |
| Volume Number | 19 |
| Language | English |
| Publisher | African Field Epidemiology Network |
| Publisher Date | 2014-01-01 |
| Publisher Place | Uganda |
| Access Restriction | Open |
| Subject Keyword | Discipline Medicine Infection Etiology Stevens-johnson Syndrome Adolescent Epidemiology Retrospective Studies Mortality Pathology Time Factors Tunisia |
| Content Type | Text |
| Resource Type | Article |
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