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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nnonyelum, Odunukwe Nkiruka Anazoeze, Madu Jude Eunice, Nnodu Obigeli Emmanuel, Okocha Onyichide Stella, Akingbola Titilola Marcus, Asuquo Inyama Taiwo, Balogun Modupe Olufela, Kalejaiye Olufunto Chinawaeze, Aneke John Orkuma, Joseph Aondowase Dalhat, Gwarzo Gwarzo Otobo, Ujah Innocent |
| Description | Author Affiliation: Nnonyelum ON ( Clinical Sciences Division, Nigerian Institute of Medical Research Lagos Nigeria.); Anazoeze MJ ( Department of Haematology and Blood Transfusion, University of Nigeria Teaching Hospital Enugu, Nigeria.); Eunice NO ( Department of Haematology College of Health Sciences University of Abuja teaching Hospital, Nigeria.); Emmanuel OO ( Department of Haematology and Blood Transfusion, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.); Stella AT ( Department of Haematology, Faculty of Basic Medical Sciences, University of Ibadan.); Marcus AI ( Department of Haematology and Blood Transfusion University of Calabar Teaching Hospital Calabar, Nigeria.); Taiwo BM ( Department of Haematology and Blood Transfusion, Lagos State University Teaching Hospital Ikeja, Nigeria.); Olufela KO ( Clinical Sciences Division, Nigerian Institute of Medical Research Lagos Nigeria.); Chinawaeze AJ ( Department of Haematology and Blood Transfusion, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.); Orkuma JA ( Department of Haematology, College of Health Sciences, Benue State University, Makurdi-Benue State.); Dalhat GG ( Department of Haematology and Blood Transfusion University of Sokoto Teaching Hospital Sokoto, Nigeria.); Otobo UI ( Clinical Sciences Division, Nigerian Institute of Medical Research Lagos Nigeria.) |
| Abstract | INTRODUCTION: Myelomatosis is a malignant proliferation of plasma cells in the bone marrow, with relatively high prevalence in African populations. Variation in genetic mutations has been observed in individual patients and may be responsible for differences in disease pattern and treatment outcomes. This study described the presentations and treatment outcomes of multiple myeloma in nigerian. METHODS: The data was obtained retrospectively from the case notes of 135 patients diagnosed with multiple myeloma from eight tertiary health institutions across the six geopolitical zones of Nigeria from 2005 to 2014. Data analysis was carried out using SPSS 17.0. RESULTS: The predominant presentations were bone pain in 97 (74%), nephropathy in 47 (35.9%) and pathological fractures in 58 (44.3%). Sixty-seven percent (67%) of the patients were less than 60 years, and 35% had Bence Jones proteinuria. The overall survival beyond 6 months was 91.3%, mean duration of survival rate was 7.4 months. Majority (66.2%) were on Melphalan alone or on melphalan-containing combinations. A higher packed cell volume (PCV) and total serum protein levels at presentation were associated with increased survival, p=0.033 and 0.036, respectively. CONCLUSION: This study portrayed the importance of detail investigation on the causes of bone pain and anaemia in person's aged 40 years and above. There is a high prevalence of nephropathy in this cohort of patients which needs to be further investigated. Majority of the patients, though < 65 years of age were placed on melphalan-containing combinations, which foreclosed chances of future autologous bone marrow transplantation. |
| File Format | HTM / HTML |
| e-ISSN | 19378688 |
| DOI | 10.11604/pamj.2015.22.292.7774 |
| Journal | Pan African Medical Journal |
| Volume Number | 22 |
| Language | English |
| Publisher | African Field Epidemiology Network |
| Publisher Date | 2015-01-01 |
| Publisher Place | Uganda |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
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