NDLI: Motivations and concerns about adolescent tuberculosis vaccine trial participation in rural Uganda: a qualitative study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Buregyeya, Esther Kulane, Asli Kiguli, Juliet Musoke, Phillipa Mayanja, Harriet Mitchell, Ellen Maeve Hanlon
Spatial Coverage	Uganda
Description	Country affiliation: Uganda Author Affiliation: Buregyeya E ( Makerere University School of Public Health, Kampala, Uganda.); Kulane A ( Institute of Global Health, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.); Kiguli J ( Makerere University School of Public Health, Kampala, Uganda.); Musoke P ( Makerere University School of Medicine, Kampala, Uganda.); Mayanja H ( Makerere University School of Medicine, Kampala, Uganda.); Mitchell EM ( KNCV Tuberculosis Foundation. The Hague, Netherlands)
Abstract	INTRODUCTION: Research is being carried out to develop and test new potentially more effective tuberculosis vaccines. Among the vaccines being developed are those that target adolescents. This study explored the stakeholders' perceptions about adolescent participation in a hypothetical tuberculosis vaccine trial in Ugandan adolescents. METHODS: Focus group discussions with adolescents, parents of infants and adolescents, and key informant interviews with community leaders and traditional healers were conducted. RESULTS: The majority of the respondents expressed potential willingness to allow their children participate in a tuberculosis vaccine trial. Main motivations for potential participation would be being able to learn about health-related issues. Hesitations included the notion that trial participation would distract the youths from their studies, fear of possible side effects of an investigational product, and potential for being sexually exploited by researchers. In addition, bad experiences from participation in previous research and doubts about the importance of research were mentioned. Suggested ways to motivate participation included: improved clarity on study purpose, risks, benefits and better scheduling of study procedures to minimize disruption to participants' academic schedules. CONCLUSION: Findings from this study suggest that the community is open to potential participation of adolescents in a tuberculosis vaccine trial. However, there is a need to communicate more effectively with the community about the purpose of the trial and its effects, including safety data, in a low-literacy, readily understood format. This raises a challenge to researchers, who cannot know all the potential effects of a trial product before it is tested.
File Format	HTM / HTML
e-ISSN	19378688
DOI	10.11604/pamj.2015.22.76.7097
Journal	Pan African Medical Journal
Volume Number	22
Language	English
Publisher	African Field Epidemiology Network
Publisher Date	2015-01-01
Publisher Place	Uganda
Access Restriction	Open
Subject Keyword	Discipline Medicine Healthy Volunteers Psychology Patient Acceptance Of Health Care Tuberculosis Vaccines Administration & Dosage Tuberculosis Prevention & Control Adolescent Clinical Trials As Topic Health Knowledge, Attitudes, Practice Motivation Rural Population Uganda Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article

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