NDLI: Systemic sarcoidosis complicated of acute renal failure: about 12 cases.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mahfoudhi, Madiha Mamlouk, Habiba Turki, Sami Kheder, Adel
Description	Country affiliation: Tunisia Author Affiliation: Mahfoudhi M ( Internal Medicine A Department, Charles Nicolle Hospital, Tunis, Tunisia.); Mamlouk H ( Internal Medicine A Department, Charles Nicolle Hospital, Tunis, Tunisia.); Turki S ( Internal Medicine A Department, Charles Nicolle Hospital, Tunis, Tunisia.); Kheder A ( Internal Medicine A Department, Charles Nicolle Hospital, Tunis, Tunisia.)
Abstract	The sarcoidosis is a systemic granulomatosis affecting most frequently the lungs and the mediastinum. An acute renal failure reveals exceptionally this disease. It's a retrospective study implicating 12 cases of sarcoidosis complicated of acute renal failure. The aim of this study is to determine epidemiological, clinical, biological and histological profile in these cases and then to indicate the interest to consider the diagnosis of sarcoidosis in cases of unexplained renal failure. Extra-renal complications, therapeutic modalities and the outcome were determined in all patients. Our series involved 12 women with an average age of 40 years. Biological investigations showed an abnormal normocalcemia in 7 cases, a hypercalcemia in 5 cases, a hypercalciuria in 10 cases and polyclonal hypergammaglobulinemia in 7 cases. An acute renal failure was found in all patients with a median creatinin of 520 umol/L. For all patients, the renal echography was normal however, the kidney biopsy showed tubulo-interstitial nephritis. The extra-renal signs highlighting pulmonary interstitial syndrome in 5 cases, a sicca syndrome in 4 cases, mediastinal lymph nodes in 2 cases, a lymphocytic alveolitis in 3 cases, an anterior granulomatous uveitis in 2 cases and a polyarthritis in 5 cases. Five patients benefited of hemodialysis. The treatment consisted of corticosteroid in all cases. The follow up was marked by complete resolution of clinical and biological signs. The diagnosis of renal sarcoidosis must be done quickly to prevent renal failure.
File Format	HTM / HTML
e-ISSN	19378688
DOI	10.11604/pamj.2015.22.75.6237
Journal	Pan African Medical Journal
Volume Number	22
Language	English
Publisher	African Field Epidemiology Network
Publisher Date	2015-01-01
Publisher Place	Uganda
Access Restriction	Open
Subject Keyword	Discipline Medicine Acute Kidney Injury Etiology Nephritis, Interstitial Renal Dialysis Sarcoidosis Complications Epidemiology Therapy Adrenal Cortex Hormones Therapeutic Use Calcium Blood Diagnosis Retrospective Studies
Content Type	Text
Resource Type	Article

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