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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Long, Zhi-Min Bi, Kai-Shun Huo, Yan-Shuang Yan, Xiao-Yu Zhao, Xu Chen, Xiao-Hui |
| Description | Author Affiliation: Long ZM ( School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR China.) |
| Abstract | A sensitive and efficient liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for the simultaneous determination of geniposide, 6 -hydroxygeniposide, and genipin gentiobioside in rat plasma. After the addition of internal standard (I.S.) salidroside and acidification (formic acid, 0.1%), plasma samples were carried out by protein precipitation with acetonitrile and separated on a Kromasil C(18) column (200 mm × 4.6 mm, 5 µm) within a runtime of 15.0 min. The linear ranges were 2-250 ng/mL for both 6 -hydroxygeniposide and genipin gentiobioside and 2-2000 ng/mL for geniposide, respectively. The lower limit of quantification (LLOQ) was 2 ng/mL for all the analytes. The validated method was successfully applied to the pharmacokinetics study of geniposide, 6 -hydroxygeniposide, and genipin gentiobioside in rats after oral administration of Zhi-zi-chi decoction. |
| File Format | HTM / HTML |
| ISSN | 16159306 |
| Issue Number | 20 |
| Volume Number | 34 |
| e-ISSN | 16159314 |
| Journal | Journal of Separation Science |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2011-10-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Drugs, Chinese Herbal Administration & Dosage Gardenia Chemistry Iridoids Blood Mass Spectrometry Methods Soybeans Administration, Oral Animals Chromatography, High Pressure Liquid Male Rats Rats, Wistar Evaluation Studies Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Filtration and Separation |
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