NDLI: Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wangchuk, Phurpa Keller, Paul A. Pyne, Stephen G. Willis, Anthony C. Kamchonwongpaisan, Sumalee
Spatial Coverage	Bhutan
Description	Country affiliation: Australia Author Affiliation: Wangchuk P ( School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.)
Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Corydalis dubia is used in Bhutanese traditional medicine as a febrifuge and for treating infections in the blood, liver and bile which correlate to the signs and symptoms of malarial and microbial infections. AIM OF THE STUDY: To validate the ethnopharmacological uses of the plant and to discover potential new therapeutic drug leads. MATERIALS AND METHODS: C. dubia was collected from Bhutan and the alkaloids were obtained using acid-base fractionation and separation by repeated column and preparative plate chromatography. The alkaloids were identified from analysis of their physiochemical and spectroscopic data and were tested for antiplasmodial, antimicrobial and cytotoxicity activities. RESULTS: A systematic extraction and isolation protocol yielded one new natural product, dubiamine, and seven known isoquinoline alkaloids, scoulerine, cheilanthifoline, protopine, capnoidine, bicuculline, corydecumbine and hydrastine. Among the four alkaloids tested, scoulerine showed the best antiplasmodial activity with IC(50) values of 5.4µM and 3.1µM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively. None of the alkaloids tested showed significant antimicrobial or cytotoxicity activities. CONCLUSIONS: The antiplasmodial test results, of the isolated alkaloid components, are commensurated with the ethnopharmacological uses of this plant.
File Format	HTM / HTML
ISSN	03788741
Issue Number	1
Volume Number	143
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-08-30
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Alkaloids Isolation & Purification Pharmacology Antimalarials Berberine Alkaloids Corydalis Chemistry Isoquinolines Plant Extracts Plasmodium Falciparum Drug Effects Bhutan Drug Resistance Inhibitory Concentration 50 Medicine, Traditional Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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