NDLI: Mechanisms of blood glucose-lowering effect of aqueous extract from stems of Kothala himbutu (Salacia reticulata) in the mouse.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Im, Ryanghyok Mano, Hiroshi Matsuura, Tomokazu Nakatani, Sachie Shimizu, Jun Wada, Masahiro
Spatial Coverage	Sri Lanka
Description	Country affiliation: Japan Author Affiliation: Im R ( Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.)
Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Kothala himbutu (Salacia reticulata) is a medicinal plant that has been used in Ayurvedic system of Indian and Sri Lankan traditional medicine to treat diabetes. AIM OF THE STUDY: This study aimed to clarify the mechanism(s) by which aqueous extracts of Kothala himbutu (KTE) stems decreases fasting blood glucose levels. MATERIALS AND METHODS: Gene expression profiles were assessed by DNA microarray and RT-PCR analyses of RNA from the liver of KK-Ay diabetic mice administered KTE or control distilled water for 4 weeks, and from cultured liver cells treated with freeze-dried KTE (KTED) or selected phenolic compounds. RESULTS: DNA microarray and RT-PCR analyses revealed that gluconeogenic fructose-1,6-bisphosphatase (FBP) was decreased compared with the control in KTE-treated KK-Ay mice. RT-PCR analysis using cultured liver cells treated with KTED and/or actinomycin D or cycloheximide, revealed that KTED directly decreased FBP mRNA levels via destabilization of the mRNA. One compound in KTE, mangiferin, was demonstrated to dose-dependently down-regulate FBP mRNA. CONCLUSIONS: These findings suggest that the mangiferin in KTE acts directly on liver cells and down-regulates the gluconeogenic pathway through regulation of FBP expression, thereby decreasing fasting blood glucose levels in mice. Our results demonstrate that gluconeogenic gene regulation is one possible mechanism by which KT exerts its effects in traditional diabetic medicine.
File Format	HTM / HTML
ISSN	03788741
Issue Number	2
Volume Number	121
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2009-01-21
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Blood Glucose Drug Effects Plant Extracts Pharmacology Salacia Chemistry Xanthones Animals Cell Line Diabetes Mellitus, Experimental Drug Therapy Physiopathology Dose-response Relationship, Drug Fructose-bisphosphatase Metabolism Gene Expression Regulation Gluconeogenesis Liver Male Medicine, Ayurvedic Mice Oligonucleotide Array Sequence Analysis Administration & Dosage Plant Stems Rna, Messenger Reverse Transcriptase Polymerase Chain Reaction Sri Lanka Isolation & Purification Journal Article
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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