NDLI: Investigations of antimicrobial activity of some Cameroonian medicinal plant extracts against bacteria and yeast with gastrointestinal relevance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tekwu, Emmanuel Mouafo Pieme, Anatole Constant Beng, Véronique Penlap
Spatial Coverage	Cameroon
Description	Author Affiliation: Tekwu EM ( Laboratory of Microbiology, Department of Biochemistry, Faculty of Science/Laboratory for Tuberculosis Research, Biotechnology Centre, University of Yaoundé I, Yaoundé-Cameroon, PO Box 812, Yaoundé. etekwu@yahoo.fr)
Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Resistance against antibiotics of many bacteria is accumulating. Therefore, searches for new substances with antimicrobial activity have become an urgent necessity. Medicinal plants are frequently used in popular medicine as remedies for many infectious diseases (intestinal infection, malaria, tuberculosis, etc.). AIM OF THE STUDY: This study aimed to determine the in vitro antimicrobial activity of hexane, ethyl acetate and methanol extracts from different parts (leaves, stem bark, entire plant) of five different plant species against bacteria and yeast of gastrointestinal relevance. MATERIAL AND METHODS: Twenty-one extracts from all the following plants (Albizia gummifera (leaf), Ficus exasperata (leaf and stem bark), Nauclea latifolia (leaf and stem bark), Ricinodendron heudelotii (stem bark), Senna hirsuta (entire plant) have been screened for their antimicrobial activity against eight bacteria species including Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus), Gram-negative bacteria (Escherichia coli, Shigella dysenteriae, Shigella flexneri, Salmonella typhi, Pseudomonas aeruginosa, and Klebsiella pneumoniae) and one yeast species (Candida albicans) using agar disc-diffusion, and microbroth dilution assays. RESULTS: Results demonstrated that F. exasperata and N. latifolia were active against the whole set of tested microorganisms. The methanol extract of N. latifolia (leaf and stem bark) was the most active against against C. albicans, E. coli, S. aureus, P. aeruginosa with a minimum inhibitory concentration (MIC) of 2, 32, 64 and 64 µg/ml, respectively. The methanol extract of leaf of F. exasperata was also most active with significant inhibitory activity against E. coli, S. dysenteriae, S. Typhi and P. aeruginosa with MIC values of 128 µg/ml. Only the extract of N. latifolia (stem bark and leaf) showed anticandidal property. CONCLUSION: The results show that these plant extracts exhibit antimicrobial activity and N. latifolia proved to be most effective as an antibacterial and antifungal.
File Format	HTM / HTML
ISSN	03788741
Issue Number	1
Volume Number	142
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-06-26
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Angiosperms Anti-bacterial Agents Pharmacology Antifungal Agents Plant Extracts Plants, Medicinal Bacteria Drug Effects Cameroon Candida Albicans Gastrointestinal Tract Microbiology Microbial Sensitivity Tests Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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