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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Hyungwoo Lee, Mi Ran Lee, Guem San An, Won Gun Cho, Su In |
| Description | Country affiliation: South Korea Author Affiliation: Kim H ( School of Korean Medicine, Pusan National University, Pusan 626-870, South Korea. kronos7@pusan.ac.kr) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: The dried root of Sophora flavescens Aiton (Sophorae radix, SR) has long been used in traditional medicine for the treatment of fever and swelling in eastern countries. MATERIALS AND METHODS: The present study investigated the anti-allergic and anti-inflammatory effects of SR using 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model and in vitro using RBL-2H3 cells. RESULTS: In mice, the topical application of 10 mg/mL of SR effectively inhibited enlargement of ear thickness and weight induced by repeated painting with DNFB. Topical application of SR also inhibited hyperplasia, edema, spongiosis and infiltration of mononuclear cells in ear tissue. In addition, production levels of interferon-gamma and tumor necrosis factor-alpha were decreased by SR in vivo. Finally, the release of histamine and ß-hexosaminidase, and migration were inhibited by treatment with SR. CONCLUSIONS: These data indicate the potential of SR in treating patients with allergic skin diseases and also suggest that related mechanisms are involved in anti-inflammatory action on the Th 1 skewing reaction and inhibition against recruitment and degranulation of mast cells. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 1 |
| Volume Number | 142 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-26 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Anti-allergic Agents Therapeutic Use Anti-inflammatory Agents Dermatitis, Allergic Contact Drug Therapy Edema Plant Extracts Sophora Animals Pharmacology Cell Degranulation Drug Effects Cell Line Cell Line, Tumor Immunology Dinitrofluorobenzene Chemically Induced Pathology Histamine Release Interferon-gamma Male Mast Cells Physiology Mice Mice, Inbred Balb C Phytotherapy Plant Roots Rats Tumor Necrosis Factor-alpha Beta-n-acetylhexosaminidases Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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