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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yao, Hsien-Tsung Chang, Yi-Wei Uramaru, Naoto Watanabe, Yoko Kitamura, Shigeyuki Kuo, Yueh-Hsiung Lii, Chong-Kuei Yeh, Teng-Kuang |
| Description | Country affiliation: Taiwan Author Affiliation: Yao HT ( Department of Nutrition, China Medical University, 91 Hsueh-Shih Road, Taichung 404, Taiwan. htyao@mail.cmu.edu.tw) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Bu-Zhong-Yi-Qi-Tang (BT) is the dry powder derived from the aqueous extract of a mixture of 10 medicinal herbs. It is a traditional Chinese medicine being used for the treatment of various immune-related diseases. AIM OF THE STUDY: To investigate the effect of BT on hepatic drug-metabolizing enzymes and its effect on plasma concentrations of tolbutamide, a substrate of CYP2C, in rats. MATERIALS AND METHODS: EXP 1: Thirty-two male Wistar rats were divided into four groups. Rats were fed a control diet and a control diet containing 1, 2.5 and 5% (w/w) of BT, respectively, for eight weeks. The activities of the major CYP and Phase II conjugating enzymes in rat liver microsomes as well as the antioxidant system in rat liver were assessed. Exp 2: Male Wistar rats were fed a control diet or a control diet containing 2.5% of BT, respectively, for eight weeks. A single 20-mg/kg oral dose of tolbutamide was then administered to each rat. Plasma samples were collected from each rat at 0.5, 1, 2, 4 and 8h after dosing. The concentrations of tolbutamide and glucose level in plasma were determined by high-performance liquid chromatography-mass spectrometer (HPLC/MS) and enzymatic method, respectively. RESULTS: Significant decrease in microsomal CYP2C-catalyzed diclofenac 4-hydroxylation in the liver of rats fed the BT diet was observed. Increased UDP-glucuronosyltransferase (UGT) and glutathione S-transferase (GST) activities were also observed in the liver of rats fed the diet containing 2.5 and 5% of BT. Immunoblot analyses also showed decreases of CYP2C11 proteins in the liver of BT fed rats. In addition, rats fed the 2.5% BT diet for eight weeks had no effects on the disposition of tolbutamide and reduction of glucose level in plasma after orally administered of tolbutamide. CONCLUSIONS: Rats fed the BT diet for eight weeks may decrease CYP2C enzyme activity and protein expression and increase Phase II conjugating enzyme activities in liver. However, BT may not affect the disposition and efficacy of tolbutamide. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 1 |
| Volume Number | 142 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-26 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Cytochrome P-450 Enzyme Inhibitors Drugs, Chinese Herbal Pharmacology Enzyme Inhibitors Glucuronosyltransferase Metabolism Glutathione Transferase Liver Drug Effects Animals Blood Glucose Analysis Cytochrome P-450 Enzyme System Diet, High-fat Glutathione Humans Hypoglycemic Agents Blood Pharmacokinetics Lipid Peroxidation Male Microsomes, Liver Rats Rats, Sprague-dawley Rats, Wistar Tolbutamide Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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