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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Del Carmen Juárez-Vázquez, Maria Josabad Alonso-Castro, Angel García-Carrancá, Alejandro |
| Description | Author Affiliation: Del Carmen Juárez-Vázquez M ( División de Investigación Básica, Instituto Nacional de Cancerología, D.F., México.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Justicia spicigera is a plant used as immunostimulatory in Mexican traditional medicine. Recently, we showed that Justicia spicigera extracts exerted immunostimulatory effects and the major component of this extract was kaempferitrin (KM). This work shows a correlation between the medical traditional use of Justicia spicigera and kaempferitrin, its active compound. MATERIALS AND METHODS: The in vitro immunostimulatory effects of KM were evaluated on the proliferation of murine splenocytes and macrophages, and human peripheral blood mononuclear cells (PBMC). The effects of KM on NO production, lysosomal enzyme activity and neutral red uptake were assayed in murine macrophages RAW 264.7. The effects of KM on the NK cell activity were also assayed. RESULTS: KM at 25µM, the highest concentration tested, increased the proliferation of murine macrophages (23%) and splenocytes (17%), and human PBMC (24%) in the absence of lipopolysaccharides (LPS), compared to untreated cells. KM also stimulated the pinocytosis (25%) and lysosomal enzyme activity (57%) in murine macrophages with a similar potency than LPS 1µg/ml. In addition, KM induced the NK cell activity (11%). CONCLUSION: KM exerts immunostimulatory effects on immune responses mediated by splenocytes, macrophages, PBMC and NK cells. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 1 |
| Volume Number | 148 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-06-21 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Adjuvants, Immunologic Pharmacology Kaempferols Animals Cell Line Cell Proliferation Drug Effects Cell Survival Cells, Cultured Humans Killer Cells, Natural Immunology Leukocytes, Mononuclear Lipopolysaccharides Lysosomes Metabolism Macrophages Mice Mice, Inbred C57bl Nitric Oxide Spleen Cytology Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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