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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jamil, Mohd Fadzly Amar Subki, Mohd Ferdaues Mohd Lan, Tan Mei Majid, Mohamed Isa Abdul Adenan, Mohd Ilham |
| Description | Country affiliation: Malaysia Author Affiliation: Jamil MF ( Malaysian Institute Pharmaceuticals and Nutraceuticals (IPharm), Ministry of Science, Technology and Innovation (MOSTI) Jalan Bukit Gambir, 11700 Gelugor Pulau Pinang, Malaysia.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: [corrected] Mitragynine is an indole alkaloid compound of Mitragyna speciosa (M. speciosa) Korth. (Rubiaceae). This plant is native to the southern regions of Thailand and northern regions of Malaysia and is frequently used to manage the withdrawal symptoms in both countries. AIM OF STUDY: To investigate the effect of mitragynine after chronic morphine treatment on cyclic AMP (cAMP) level and mRNA expression of mu-opioid receptor (MOR) in human neuroblastoma SK-N-SH cell. METHOD AND MATERIALS: Mitragynine was isolated from the Mitragyna speciosa plant using the acid-base extraction method. The cAMP level upon forskolin stimulation in the cells was determined using the Calbiochem(®) Direct Immunoassay Kit. The mRNA expression of the MOR was carried out using quantitative RT-PCR. RESULT: Cotreatment and pretreatment of morphine and mitragynine significantly reduced the production of cAMP level at a lower concentration of mitragynine while the higher concentration of this compound could lead to the development of tolerance and dependence as shown by the increase of the cAMP level production in foskolin stimulation. In MOR mRNA expression study, cotreatment of morphine with mitragynine significantly reduced the down-regulation of MOR mRNA expression as compared to morphine treatment only. CONCLUSION: These finding suggest that mitragynine could possibly avoid the tolerance and dependence on chronic morphine treatment by reducing the up-regulation of cAMP level as well as reducing the down-regulation of MOR at a lower concentration of mitragynine. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 1 |
| Volume Number | 148 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-06-21 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Analgesics, Opioid Administration & Dosage Cyclic Amp Metabolism Morphine Receptors, Opioid, Mu Genetics Secologanin Tryptamine Alkaloids Cell Differentiation Cell Line, Tumor Humans Mitragyna Plant Leaves Rna, Messenger Substance-related Disorders Tretinoin Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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