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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Alerico, Gabriela C. Beckenkamp, Aline Vignoli-Silva, Márcia Buffon, Andréia Von Poser, Gilsane L. |
| Spatial Coverage | Brazil |
| Description | Country affiliation: Brazil Author Affiliation: Alerico GC ( Laboratório de Farmacognosia, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre, RS 90610-000, Brazil.); Beckenkamp A ( Laboratório de Análises Bioquímicas, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre, RS 90610-000, Brazil.); Vignoli-Silva M ( Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite 245, Porto Alegre, RS 90050-170, Brazil.); Buffon A ( Laboratório de Análises Bioquímicas, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre, RS 90610-000, Brazil.); von Poser GL ( Laboratório de Farmacognosia, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752, Porto Alegre, RS 90610-000, Brazil. Electronic address: gilsane@farmacia.ufrgs.br.) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Wounds are normally resolved in a few days, but chronic wounds represent a major burden because of economic and social factors. Thereby, the search for new agents is ongoing and natural products become a great target. Also, Brazil as a consumer of herbal medicines with rich social diversity is promising for ethnopharmacological studies. AIMS OF THE STUDY: The study aims to find the plants popularly used for wound healing purposes in Rio Grande do Sul state, and test the traditional knowledge through an in vitro screening. MATERIALS AND METHODS: Ethnobotanical studies from state of Rio Grande do Sul were analyzed to find the most used plants to treat wounds. The selected species were collected, identified and ethanolic and aqueous extracts were prepared. After, proliferative capacity was accessed by MTT assay in a keratinocyte cell line (HaCaT). RESULTS: The survey comprehended almost all state regions and led to 117 plant species from 85 genera, from which 14 were selected for in vitro testing. Aqueous extracts from Achyrocline satureioides DC Lam., Matricaria recutita L., Melia azedarach L. and Mirabilis jalapa L. demonstrated the ability to stimulate keratinocyte growth up to 120% in concentrations of 25 µg/mL and 50 µg/mL. The ethanolic extract of A. satureioides was able to stimulate keratinocyte and fibroblast proliferation on the lower concentration tested, 1 µg/mL, being the most promising species. CONCLUSIONS: The traditional knowledge collected from the ethnobotanical studies was accessed by in vitro investigation and extracts from Achyrocline satureioides, Matricaria recutita, Melia azedarach and Mirabilis jalapa can influence positively cell proliferation. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Volume Number | 176 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-12-24 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Cell Proliferation Drug Effects Plants, Medicinal Brazil Cell Line Fibroblasts Humans Keratinocytes Plant Extracts Pharmacology Wound Healing Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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