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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Greaney, Jody L. Alexander, Lacy M. Kenney, W. Larry |
| Description | Author Affiliation: Greaney JL ( Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, Pennsylvania jlg52@psu.edu.); Alexander LM ( Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, Pennsylvania.); Kenney WL ( Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, Pennsylvania.) |
| Abstract | This Synthesis highlights a series of recent studies that has systematically interrogated age-related deficits in cold-induced skin vasoconstriction. In response to cold stress, a reflex increase in sympathetic nervous system activity mediates reductions in skin blood flow. Reflex vasoconstriction during cold exposure is markedly impaired in aged skin, contributing to the relative inability of healthy older adults to maintain core temperature during mild cold stress in the absence of appropriate behavioral thermoregulation. This compromised reflex cutaneous vasoconstriction in healthy aging can occur as a result of functional deficits at multiple points along the efferent sympathetic reflex axis, including blunted sympathetic outflow directed to the skin vasculature, reduced presynaptic neurotransmitter synthesis and/or release, and altered end-organ responsiveness at several loci, in addition to potential alterations in afferent thermoreceptor function. Arguments have been made that the relative inability of aged skin to appropriately constrict is due to the aging cutaneous arterioles themselves, whereas other data point to the neural circuitry controlling those vessels. The argument presented herein provides strong evidence for impaired efferent sympathetic control of the peripheral cutaneous vasculature during whole body cold exposure as the primary mechanism responsible for attenuated vasoconstriction. |
| File Format | HTM / HTML |
| ISSN | 87507587 |
| e-ISSN | 15221601 |
| Journal | Journal of Applied Physiology |
| Issue Number | 7 |
| Volume Number | 119 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2015-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Aging Physiology Skin Blood Supply Sympathetic Nervous System Vasoconstriction Body Temperature Regulation Regional Blood Flow Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Sports Science |
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