NDLI: Peripheral mechanisms of thermoregulatory control of skin blood flow in aged humans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Holowatz, Lacy A. Kenney, W. Larry
Description	Country affiliation: United States Author Affiliation: Holowatz LA ( Department of Kinesiology, The Pennsylvania State University, Noll Laboratory, University Park, PA 16802, USA. Lma191@psu.edu)
Abstract	Human skin blood flow is controlled via dual innervation from the sympathetic nervous system. Reflex cutaneous vasoconstriction and vasodilation are both impaired with primary aging, rendering the aged more vulnerable to hypothermia and cardiovascular complications from heat-related illness. Age-related alterations in the thermoregulatory control of skin blood flow occur at multiple points along the efferent arm of the reflex, including 1) diminished sympathetic outflow, 2) altered presynaptic neurotransmitter synthesis, 3) reduced vascular responsiveness, and 4) impairments in downstream (endothelial and vascular smooth muscle) second-messenger signaling. This mechanistic review highlights some of the recent findings in the area of aging and the thermoregulatory control of skin blood flow.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.00338.2010
Journal	Journal of Applied Physiology
Issue Number	5
Volume Number	109
Language	English
Publisher	American Physiological Society
Publisher Date	2010-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Aging Body Temperature Regulation Hemodynamics Microvessels Skin Blood Supply Sympathetic Nervous System Physiology Microcirculation Regional Blood Flow Vasoconstriction Vasodilation
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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