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Color-coded real-time cellular imaging of lung T-lymphocyte accumulation and focus formation in a mouse asthma model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hasegawa, Akihiro Hayashi, Katsuhiro Kishimoto, Hiroyuki Yang, Meng Tofukuji, Soichi Suzuki, Kazuo Nakajima, Hiroshi Hoffman, Robert M. Shirai, Mutsunori Nakayama, Toshinori
Description	Country affiliation: Japan Author Affiliation: Hasegawa A ( Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.)
Abstract	BACKGROUND: A critical role for CD4(+)T(H)2 cells in the pathogenesis of acute asthma has been demonstrated in the studies of human asthma as well as of animal models of asthma. T(H)2-cell migration into the lung is crucial for the initiation of asthma phenotype, but the dynamics of this process are poorly understood because it has been difficult to visualize this process. OBJECTIVE: Our aim was to image the cellular dynamics of the migration of T(H)2 cells into the lung of living animals in a mouse model of asthma and identify the cellular processes required for the initiation of the asthma phenotype. METHODS: We developed a color-coded real-time imaging model of cell migration into the lung using green fluorescent protein (GFP) and red fluorescent protein (RFP) transgenic CD4 T cells. RESULTS: Selective accumulation of antigen-specific CD4 T cells in the lungs was quantitatively imaged in a mouse model of asthma. The inhibition of accumulation by dexamethasone was imaged. Accumulating GFP(+) T(H)2 cells formed foci in the lungs from 6 to 20 hours after antigen inhalation. This process was also inhibited by the administration of anti-intercellular adhesion molecule 1 or anti-vascular cell adhesion molecule 1 mAbs. Two days after inhalation of antigen, GFP(+) T(H)2 cells were detected in the area of eosinophil infiltration. CONCLUSION: Focus formation generated by accumulating antigen-specific T(H)2 cells in the lung appeared to be a critical process in the initiation of the asthma phenotype. This new model enables the study of in vivo cell biology of airway inflammation and novel drug discovery for lung inflammatory diseases.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
Journal	Journal of Allergy and Clinical Immunology
Issue Number	2
Volume Number	125
Language	English
Publisher	Elsevier
Publisher Date	2010-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Asthma Immunology Cd4-positive T-lymphocytes Diagnostic Imaging Lung Cytology Animals Disease Models, Animal Green Fluorescent Proteins Immunohistochemistry Luminescent Proteins Mice Mice, Inbred C57bl Mice, Transgenic Microscopy, Confocal Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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