NDLI: Natural killer cell deficiency.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Orange, Jordan S.
Description	Country affiliation: United States Author Affiliation: Orange JS ( Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, USA. orange@bcm.edu)
Abstract	Natural killer (NK) cells are part of the innate immune defense against infection and cancer and are especially useful in combating certain viral pathogens. The utility of NK cells in human health has been underscored by a growing number of persons who are deficient in NK cells and/or their functions. This can be in the context of a broader genetically defined congenital immunodeficiency, of which there are more than 40 presently known to impair NK cells. However, the abnormality of NK cells in certain cases represents the majority immunologic defect. In aggregate, these conditions are termed NK cell deficiency. Recent advances have added clarity to this diagnosis and identified defects in 3 genes that can cause NK cell deficiency, as well as some of the underlying biology. Appropriate consideration of these diagnoses and patients raises the potential for rational therapeutic options and further innovation.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
DOI	10.1016/j.jaci.2013.07.020
Journal	Journal of Allergy and Clinical Immunology
Issue Number	3
Volume Number	132
Language	English
Publisher	Elsevier
Publisher Date	2013-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Immunologic Deficiency Syndromes Immunology Killer Cells, Natural Disease Susceptibility Genetics Therapy Virus Diseases Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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