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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yokoyama, Wayne M. Vivier, Eric Zitvogel, Laurence Caligiuri, Michael A. Raulet, David H. Lanier, Lewis L. Ugolini, Sophie Moretta, Alessandro |
| Description | Author Affiliation: Vivier E ( Centre d'Immunologie de Marseille-Luminy (CIML), Université de la Méditerranée UM 631, Campus de Luminy, 13288 Marseille, France. vivier@ciml.univ-mrs.fr) |
| Abstract | Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK cells has emerged. NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development. Moreover, NK cells do not react in an invariant manner but rather adapt to their environment. Finally, recent studies have unveiled that NK cells can also mount a form of antigen-specific immunologic memory. NK cells thus exert sophisticated biological functions that are attributes of both innate and adaptive immunity, blurring the functional borders between these two arms of the immune response. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6013 |
| Volume Number | 331 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2011-01-07 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adaptive Immunity Immunity, Innate Killer Cells, Natural Immunology Animals Immunologic Memory Neoplasms Therapy Receptors, Immunologic Metabolism Self Tolerance Virus Diseases Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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