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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cao, Rong-An Lee, YongJin You, SangGuan |
| Description | Country affiliation: South Korea Author Affiliation: Cao RA ( College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China); Lee Y ( Chuncheon Bioindustry Foundation, Chuncheon, Gangwon 200-957, South Korea. Electronic address: yjlee67123@hanmail.net.); You S ( Department of Marine Food Science and Technology, Gangneung-Wonju National University, 120 Gangneung Daehangno, Gangneung, Gangwon 210-702, South Korea. Electronic address: umyousg@gwnu.ac.kr.) |
| Abstract | Water-soluble sulfated fucans isolated from Ecklonia cava were fractionated using an anion-exchange chromatography to investigate their molecular characteristics and immunomodulating activities. The crude fucoidan extract and purified fractions (EF1, EF2, and EF3) consisted mostly of different ratios of neutral sugars, proteins, sulfates, uronic acids, and their monosaccharide compositions were also significantly different. The backbone of the most immunoenhancing fraction, EF2, was mainly linked by (1â3)-linked fucopyranosyl and (1â4)-linked mannopyranosyl residues with sulfates at C-4 of fucopyranosyl units. The molecular weights of the crude fucoidan extract and purified fractions ranged from 8.3×10(3) to 442.6×10(3)g/mol. The crude extract, EF1 and EF2 stimulated RAW264.7 cells to produce considerable amounts of nitric oxide and cytokines. The treatment of cells with the sulfated fucans induced the degradation of Iκ-B and the phosphorylation of MAPK in RAW264.7 cells, implying that they might stimulate RAW264.7 cells through the activation of NF-κB and MAPK pathways. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 67 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Immunologic Factors Isolation & Purification Phaeophyta Immunology Plant Extracts Chemistry Polysaccharides Animals Cell Line Drug Effects Mice Nf-kappa B Biosynthesis Nitric Oxide Administration & Dosage Solubility Water Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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