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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lu, Bitao Wang, Tianyou Li, Zhiquan Dai, Fangying Lv, Lingmei Tang, Fengling Yu, Kun Liu, Jiawei Lan, Guangqian |
| Description | Country affiliation: China Author Affiliation: Lu B ( College of Textile and Garments, Southwest University, Chongqing 400715, China.); Wang T ( College of Textile and Garments, Southwest University, Chongqing 400715, China.); Li Z ( The Ninth People's Hospital of Chongqing, Chongqing 400715, China.); Dai F ( College of Textile and Garments, Southwest University, Chongqing 400715, China); Lv L ( College of Textile and Garments, Southwest University, Chongqing 400715, China.); Tang F ( College of Textile and Garments, Southwest University, Chongqing 400715, China.); Yu K ( College of Textile and Garments, Southwest University, Chongqing 400715, China.); Liu J ( College of Textile and Garments, Southwest University, Chongqing 400715, China.); Lan G ( College of Textile and Garments, Southwest University, Chongqing 400715, China) |
| Abstract | A chitosan-gelatin sponge (CSGT) was prepared using a chitosan/ascorbic acid solution blend containing gelatin, followed by crosslinking with tannin acid and freeze-drying, thereby combining the chitosan sponge and gelatin sponge. The structure of the CSGT was observed by scanning electron microscopy and was shown to have uniform and abundant pores measuring about 145-240µm in size. We also characterized the sponges by infrared spectroscopy, thermogravimetric analysis, mechanical property tests, swelling behavior analysis, water retention capacity tests, antibacterial property analysis, and cytotoxicity tests. Our data showed that the CSGT had good thermostability and mechanical properties as well as efficient water absorption and retention capacities. Moreover, the CSGT could effectively inhibit the growth of Escherichia coli and Staphylococcus aureus with low toxicity. In animal experiments, macroscopic observations and histological examinations showed that the wound covered by the CSGT healed quickly. Additionally, loading of the CSGT with platelet-rich plasma resulted in further acceleration of wound healing. Therefore, the CSGT and the CSGT with platelet-rich plasma were suitable for application as a wound dressing and may have potential for use in various biomedical applications. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 82 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Chitosan Chemistry Gelatin Sponge, Absorbable Gelatin Platelet-rich Plasma Skin Drug Effects Pathology Tannins Administration & Dosage Wound Healing Animals Anti-bacterial Agents Pharmacology Cell Line Cell Survival Mechanical Phenomena Mice Microbial Sensitivity Tests Porosity Spectroscopy, Fourier Transform Infrared Toxicity Thermodynamics Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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