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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sionkowska, Alina Kaczmarek, Beata Lewandowska, Katarzyna Grabska, Sylwia Pokrywczynska, Marta Kloskowski, Tomasz Drewa, Tomasz |
| Description | Author Affiliation: Sionkowska A ( Nicolaus Copernicus University in Torun, Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, Gagarin 7, 87-100 Torun, Poland. Electronic address: as@chem.umk.pl.); Kaczmarek B ( Nicolaus Copernicus University in Torun, Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, Gagarin 7, 87-100 Torun, Poland.); Lewandowska K ( Nicolaus Copernicus University in Torun, Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, Gagarin 7, 87-100 Torun, Poland.); Grabska S ( Nicolaus Copernicus University in Torun, Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, Gagarin 7, 87-100 Torun, Poland.); Pokrywczynska M ( Nicolaus Copernicus University in Torun, Ludwik Rydygier Medical College in Bydgoszcz, Faculty of Medicine, Chair of Urology, Department of Regenerative Medicine, Karlowicza 24 Street, 85-092 Bydgoszcz, Poland.); Kloskowski T ( Nicolaus Copernicus University in Torun, Ludwik Rydygier Medical College in Bydgoszcz, Faculty of Medicine, Chair of Urology, Department of Regenerative Medicine, Karlowicza 24 Street, 85-092 Bydgoszcz, Poland.); Drewa T ( Nicolaus Copernicus University in Torun, Ludwik Rydygier Medical College in Bydgoszcz, Faculty of Medicine, Chair of Urology, Department of Regenerative Medicine, Karlowicza 24 Street, 85-092 Bydgoszcz, Poland.) |
| Abstract | 3D porous composites based on blends of chitosan, collagen and hyaluronic acid were obtained through the lyophilization process. Mechanical properties, swelling behavior and thermal stability of the blends were studied. Moreover, SEM images were taken and the structure of the blends was studied. Biological properties of the materials obtained were investigated by analyzing of proliferation rate of fibroblast cells incubated with biomaterial extract using MTT assay (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide). The results showed that the properties of 3D composites based on the blends of chitosan and collagen were altered after the addition 1%, 2% and 5% of hyaluronic acid. Mechanical properties and thermal stability of chitosan/collagen blends were improved in the presence of hyaluronic acid in the composite. New 3D materials based on the blends of chitosan, collagen and hyaluronic acid were non-toxic and did not significantly affect cell morphology. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Journal | International Journal of Biological Macromolecules |
| Volume Number | 89 |
| e-ISSN | 18790003 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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