NDLI: Lymphoid neogenesis and immune infiltration in aged liver.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Singh, Pallavi Coskun, Zeynep Z. Goode, Catriona Dean, Adam Thompson-Snipes, LuAnn Darlington, Gretchen
Description	Country affiliation: United States Author Affiliation: Singh P ( Molecular & Human Genetics Department, Baylor College of Medicine, Houston, TX 77030, USA. ps139913@bcm.tmc.edu)
Abstract	UNLABELLED: Immune dysregulation and inflammation play a major role in the pathology of age-related disorders. In an earlier study, the microarray data from our laboratory indicated an increase in inflammation-related gene expression in the liver with age. We further investigated immune-related changes in the aged liver and found that the levels of inflammatory cytokines, chemokines, and inflammatory genes were higher in aged animals. Immunohistochemical studies showed that immune cells formed clusters or foci in the livers of old mice, preferentially near the perivascular regions. Further analysis revealed an enrichment of macrophages, T cells, B cells, natural killer cells, and neutrophils in old liver. Characterization of the immune clusters showed the presence of shared markers of tertiary lymphoid neogenesis. Levels of lymph node homing cytokines were elevated. Expression of immunoglobulin and recombinase gene transcripts was also higher, indicating the presence of ectopic lymphoid structures in the aged liver. CONCLUSION: Aged liver exhibits a marked inflammatory status accompanied by increased immune cell infiltration. Inflammation and ectopic lymphoid structures have previously been shown to be associated with carcinogenesis, a condition that becomes more prevalent with age. Thus, further study of inflammation-related changes in the microenvironment of the aged liver could provide insights into these disorders.
File Format	HTM / HTML
ISSN	02709139
e-ISSN	15273350
DOI	10.1002/hep.22224
Journal	Hepatology
Issue Number	5
Volume Number	47
Language	English
Publisher	Wiley
Publisher Date	2008-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Hepatology Aging Immunology Liver Growth & Development Physiology Animal Feed Animals Housing, Animal Inflammation Genetics Physiopathology Lymphocytes Mice Mice, Inbred C57bl Isolation & Purification Reverse Transcriptase Polymerase Chain Reaction Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Hepatology

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