NDLI: Self-specific memory regulatory T cells protect embryos at implantation in mice.

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Self-specific memory regulatory T cells protect embryos at implantation in mice.

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Self-specific memory regulatory T cells protect embryos at implantation in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Klatzmann, David Churlaud, Guillaume Darrasse-Jèze, Guillaume Valdivia, Karina Chaouat, Gérard Chen, Ting Ruocco, Maria Grazia Strominger, Jack L. Bergot, Anne-Sophie Courau, Tristan
Description	Country affiliation: France Author Affiliation: Chen T ( Université Pierre et Marie Curie, University Paris 06, F-75013 Paris, France.)
Abstract	Regulatory T cells (Tregs) play crucial roles in both fetal and tumor development. We recently showed that immunosurveillance by pre-existing CD44(high)CD62L(low) activated/memory Tregs (amTregs) specific for self-Ags protects emergent tumor cells in mice. This Treg response of a memory type is more rapid than and dominates the antitumor response of tumor-specific effector T cells. In this study, we report striking similarities between the early Treg responses to embryo and tumor implantation. Tregs are rapidly recruited to uterus-draining lymph nodes and activated in the first days after embryo implantation in both syngeneic and allogeneic matings; express the markers of the amTreg subset; and are at least in part self-Ag specific, as seen in tumor emergence. Unlike in the tumor emergence setting, however, for which preimmunization against tumor Ags is sufficient for complete tumor eradication even in the presence of Tregs, Treg depletion is additionally required for high frequencies of fetus loss after preimmunization against paternal tissue Ags. Thus, amTregs play a major role in protecting embryos in both naive and preimmune settings. This role and the ensuing therapeutic potential are further highlighted by showing that Treg stimulation, directly by low-dose IL-2 or indirectly by Fms-related tyrosine kinase 3 ligand, led to normal pregnancy rates in a spontaneous abortion-prone model.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1202413
Journal	The Journal of Immunology
Issue Number	5
Volume Number	191
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Embryo Implantation Immunology Embryo, Mammalian Immune Tolerance Immunologic Memory T-lymphocytes, Regulatory Adoptive Transfer Animals Flow Cytometry Mice Mice, Inbred Balb C Mice, Inbred C57bl Neoplasms, Experimental Pregnancy Reverse Transcriptase Polymerase Chain Reaction Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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