NDLI: S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memory.

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Year: 2008 Volume: 47 Issue: 1

Year: 2007 Volume: 46

S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memory.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Jun Bardag-Gorce, Fawzia Dedes, Jennifer French, Barbara Alan Amidi, Fataneh Oliva, Joan French, Samuel William
Description	Country affiliation: United States Author Affiliation: Li J ( Harbor-UCLA Medical Center, Torrance, CA 90509, USA.)
Abstract	UNLABELLED: In previous studies, microarray analysis of livers from mice fed diethyl-1,4-dihydro-2,4,6-trimethyl-3,5-pyridine decarboxylate (DDC) for 10 weeks followed by 1 month of drug withdrawal (drug-primed mice) and then 7 days of drug refeeding showed an increase in the expression of numerous genes referred to here as the molecular cellular memory. This memory predisposes the liver to Mallory Denk body formation in response to drug refeeding. In the current study, drug-primed mice were refed DDC with or without a daily dose of S-adenosylmethionine (SAMe; 4 g/kg of body weight). The livers were studied for evidence of oxidative stress and changes in gene expression with microarray analysis. SAMe prevented Mallory Denk body formation in vivo. The molecular cellular memory induced by DDC refeeding lasted for 4 months after drug withdrawal and was not manifest when SAMe was added to the diet in the in vivo experiment. Liver cells from drug-primed mice spontaneously formed Mallory Denk bodies in primary tissue cultures. SAMe prevented Mallory Denk bodies when it was added to the culture medium. CONCLUSION: SAMe treatment prevented Mallory Denk body formation in vivo and in vitro by preventing the expression of a molecular cellular memory induced by prior DDC feeding. No evidence for the involvement of oxidative stress in induction of the memory was found. The molecular memory included the up-regulation of the expression of genes associated with the development of liver cell preneoplasia.
File Format	HTM / HTML
ISSN	02709139
e-ISSN	15273350
Journal	Hepatology
Issue Number	2
Volume Number	47
Language	English
Publisher	Wiley
Publisher Date	2008-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Hepatology Inclusion Bodies Drug Effects Liver Cytology S-adenosylmethionine Therapeutic Use Aldehydes Metabolism Animals Pathology Physiology Ultrastructure Malondialdehyde Mice Mice, Inbred C3h Oligonucleotide Array Sequence Analysis Genetics Isolation & Purification Reverse Transcriptase Polymerase Chain Reaction Zalcitabine Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Hepatology

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