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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ciapponi, L. Jackson, D. B. Mlodzik, M. Bohmann, D. |
| Description | Country affiliation: Germany Author Affiliation: Ciapponi L ( European Molecular Biology Laboratory, D-69117 Heidelberg, Germany.) |
| Abstract | During Drosophila development Fos acts downstream from the JNK pathway. Here we show that it can also mediate ERK signaling in wing vein formation and photoreceptor differentiation. Drosophila JNK and ERK phosphorylate D-Fos with overlapping, but distinct, patterns. Analysis of flies expressing phosphorylation site point mutants of D-Fos revealed that the transcription factor responds differentially to JNK and ERK signals. Mutations in the phosphorylation sites for JNK interfere specifically with the biological effects of JNK activation, whereas mutations in ERK phosphorylation sites affect responses to the EGF receptor-Ras-ERK pathway. These results indicate that the distinction between ERK and JNK signals can be made at the level of D-Fos, and that different pathway-specific phosphorylated forms of the protein can elicit different responses. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| Journal | Genes & Development |
| Issue Number | 12 |
| Volume Number | 15 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2001-06-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Calcium-calmodulin-dependent Protein Kinases Metabolism Drosophila Proteins Extracellular Signal-regulated Map Kinases Mitogen-activated Protein Kinases Proto-oncogene Proteins C-fos Signal Transduction Physiology Animals Binding Sites Genetics Drosophila Growth & Development Jnk Mitogen-activated Protein Kinases Phosphorylation Receptor Protein-tyrosine Kinases Receptor, Epidermal Growth Factor Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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