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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dickmeis, T. Mourrain, P. Saint-Etienne, L. Fischer, N. Aanstad, P. Clark, M. Strähle, U. Rosa, F. |
| Description | Country affiliation: France Author Affiliation: Dickmeis T ( Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, F-67404 Illkirch Cedex, C.U. de Strasbourg, France.) |
| Abstract | casanova (cas) mutant zebrafish embryos lack endoderm and develop cardia bifida. In a substractive screen for Nodal-responsive genes, we isolated an HMG box-containing gene, 10J3, which is expressed in the endoderm. The cas phenotype is rescued by overexpression of 10J3 and can be mimicked by 10J3-directed morpholinos. Furthermore, we identified a mutation within 10J3 coding sequence that cosegregates with the cas phenotype, clearly demonstrating that cas is encoded by 10J3. Epistasis experiments are consistent with an instructive role for cas in endoderm formation downstream of Nodal signals and upstream of sox17. In the absence of cas activity, endoderm progenitors differentiate into mesodermal derivatives. Thus, cas is an HMG box-containing gene involved in the fate decision between endoderm and mesoderm that acts downstream of Nodal signals. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| Journal | Genes & Development |
| Issue Number | 12 |
| Volume Number | 15 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2001-06-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Dna-binding Proteins Endoderm Physiology High Mobility Group Proteins Metabolism Mesoderm Protein-serine-threonine Kinases Signal Transduction Transcription Factors Zebrafish Proteins Amino Acid Sequence Animals Cell Differentiation Cytology Gastrula Gene Expression Profiling Genetics Molecular Sequence Data Nodal Protein Proteins Receptors, Transforming Growth Factor Beta Sox Transcription Factors Soxf Transcription Factors Stem Cells Transforming Growth Factor Beta Zebrafish Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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