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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kikuchi, Y. Agathon, A. Alexander, J. Thisse, C. Waldron, S. Yelon, D. Thisse, B. Stainier, D. Y. |
| Description | Country affiliation: United States Author Affiliation: Kikuchi Y ( Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0448, USA.) |
| Abstract | Early endoderm formation in zebrafish requires at least three loci that function downstream of Nodal signaling but upstream of the early endodermal marker sox17: bonnie and clyde (bon), faust (fau), and casanova (cas). cas mutants show the most severe phenotype as they do not form any gut tissue and lack all sox17 expression. Activation of the Nodal signaling pathway or overexpression of Bon or Fau/Gata5 fails to restore any sox17 expression in cas mutants, demonstrating that cas plays a central role in endoderm formation. Here we show that cas encodes a novel member of the Sox family of transcription factors. Initial cas expression appears in the dorsal yolk syncytial layer (YSL) in the early blastula, and is independent of Nodal signaling. In contrast, endodermal expression of cas, which begins in the late blastula, is regulated by Nodal signaling. Cas is a potent inducer of sox17 expression in wild-type embryos as well as in bon and fau/gata5 mutants. Cas is also a potent inducer of sox17 expression in MZoep mutants, which cannot respond to Nodal signaling. In addition, ectopic expression of cas in presumptive mesodermal cells leads to their transfating into endoderm. Altogether, these data indicate that Cas is the principal transcriptional effector of Nodal signaling during zebrafish endoderm formation. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| Journal | Genes & Development |
| Issue Number | 12 |
| Volume Number | 15 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2001-06-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Endoderm Physiology High Mobility Group Proteins Metabolism Signal Transduction Transcription Factors Zebrafish Proteins Amino Acid Sequence Animals Cell Differentiation Dna-binding Proteins Gata5 Transcription Factor Gene Expression Regulation, Developmental Classification Genetics Homeodomain Proteins Intracellular Signaling Peptides And Proteins Mesoderm Cytology Molecular Sequence Data Nodal Signaling Ligands Proteins Sox Transcription Factors Soxf Transcription Factors Sequence Homology, Amino Acid Transforming Growth Factor Beta Zebrafish Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, P.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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