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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cemek, Mustafa Aymelek, Fatih Büyükokuroglu, Mehmet Emin Karaca, Turan Büyükben, Ahmet Yilmaz, Fatma |
| Description | Country affiliation: Turkey Author Affiliation: Cemek M ( Department of Chemistry, Biochemistry Division, Faculty of Sciences and Arts, Kocatepe University, Afyonkarahisar, Turkey.) |
| Abstract | Royal Jelly (RJ) is used in the Turkish folk medicine for the treatment of number of disorders. The present study describes the hepatoprotective and antioxidant activities of the RJ against carbon tetrachloride (CCl(4))-induced acute liver damage. Sprague-Dawley rats were used for the experiment. CCl(4) (0.8 ml/kg; s.c.) and RJ (50, 100, 200mg/kg; orally) were given every other day, for 20 days. Malondialdehyde, reduced glutathione in whole blood and tissues; ceruloplasmin, sialic acid, ascorbic acid, retinol, ß-carotene and liver enzymes levels in serum were measured. Additionally, histopathological alterations in the liver were examined. RJ exerted the significant protective effect on liver damage as well as on oxidative stress induced by CCl(4), resulting in reduced lipid peroxidation and improved endogenous antioxidant defence systems. It also reduced the elevated levels of liver enzymes. Histopathological study further confirmed the hepatoprotective effect of RJ, when compared with the CCl(4) treated control groups. In conclusion, present study reveals biological evidence that supports the use of RJ in the treatment of chemical-induced hepatotoxicity. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 10 |
| Volume Number | 48 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Carbon Tetrachloride Poisoning Blood Prevention & Control Fatty Acids Pharmacology N-acetylneuraminic Acid Protective Agents Alanine Transaminase Animals Antioxidants Metabolism Ascorbic Acid Aspartate Aminotransferases Pathology Glutathione Liver Male Malondialdehyde Rats Rats, Sprague-dawley Vitamin A Vitamins Beta Carotene Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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