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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Afoulous, Samia Ferhout, Hicham Raoelison, Emmanuel Guy Valentin, Alexis Moukarzel, Béatrice Couderc, François Bouajila, Jalloul |
| Spatial Coverage | Madagascar |
| Description | Country affiliation: France Author Affiliation: Afoulous S ( Université de Toulouse, Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique, UMR CNRS 5623, Université Paul-Sabatier, 118 route de Narbonne, F-31062 Toulouse, France.) |
| Abstract | The essential oil from Cedrelopsis grevei leaves, an aromatic and medicinal plant from Madagascar, is widely used in folk medicine. Essential oil was characterized by GC-MS and quantified by GC-FID. Sixty-four components were identified. The major constituents were: (E)-ß-farnesene (27.61%), δ-cadinene (14.48%), -copaene (7.65%) and ß-elemene (6.96%). The essential oil contained a complex mixture consisting mainly sesquiterpene hydrocarbons (83.42%) and generally sesquiterpenes (98.91%). The essential oil was tested cytotoxic (on human breast cancer cells MCF-7), antimalarial (Plasmodium falciparum), antiinflammatory and antioxidant (ABTS and DPPH assays) activities. C. grevei essential oil was active against MCF-7 cell lines (IC50=21.5 mg/L), against P. falciparum, (IC50=17.5mg/L) and antiinflammatory (IC50=21.33 mg/L). The essential oil exhibited poor antioxidant activity against DPPH (IC50>1000 mg/L) and ABTS (IC50=110 mg/L) assays. A bibliographical review was carried out of all essential oils identified and tested with respect to antiplasmodial, anticancer and antiinflammatory activities. The aim was to establish correlations between the identified compounds and their biological activities (antiplasmodial, anticancer and antiinflammatory). According to the obtained correlations, 1,4-cadinadiene (R(2)=0.61) presented a higher relationship with antimalarial activity. However, only (Z)-ß-farnesene (R(2)=0.73) showed a significant correlation for anticancer activity. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 56 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Anti-inflammatory Agents Chemistry Antimalarials Antineoplastic Agents, Phytogenic Antioxidants Oils, Volatile Plant Leaves Rutaceae Pharmacology Female Gas Chromatography-mass Spectrometry Humans Inhibitory Concentration 50 Mcf-7 Cells Madagascar Plant Extracts Plants, Medicinal Plasmodium Falciparum Drug Effects Sesquiterpenes Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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